Acute Lymphoblastic Leukemia Mortality trend in the Federal District, Brazil, 2000- 2020
Tendência da mortalidade por leucemia linfoblástica aguda no Distrito Federal, Brasil, 2000-2020
DOI:
https://doi.org/10.53660/CLM-3689-24N12Palavras-chave:
Acute Lymphocytic Leukemia;, Mortality Registries;, Ecological Studies;, Time Series Studies;, BrazilResumo
Objective: To identify the trend and spatial distribution of deaths from ALL from 2000 to 2020 in the Federal District, Brazil. Method: This is ecological time series study in which data were obtained from Brazil's Mortality Information System. The population was obtained through death certificates and investigation forms of the underlying cause of death classified by code C91.0 for Acute Lymphoblastic Leukemia in the International Classification of Diseases from 2000 to 2020 in the Federal District, Brazil. Statistical analysis was performed using Prais-Winsten linear regression. Results: The deaths from ALL predominantly occurred in male (51.70%), single (60.41%), and white (52.16%) subjects, as well as in those with four to seven years of schooling (27.37%). During the last 20 years, ALL mortality increased among subjects aged 0-4 and 50-59 years, with increment rates of 9.0% and 8.7% respectively. In children, ALL generally has a short latency time, progressing more quickly and invasively. Conclusions: Knowledge regarding mortality patterns for ALL in the Federal District will allow optimizing the allocation of federal and local resources, as well as understanding gaps in diagnosis and specific therapies that still need attention on the part of public policy makers.
Downloads
Referências
AGÊNCIA NACIONAL DE VIGILÂNCIA SANITÁRIA (ANVISA). Anvisa aprova produto de terapia avançada para tratamento de câncer Disponível em: https://www.gov.br/anvisa/pt-br/assuntos/noticias-anvisa/2022/anvisa-aprova-produto-de-terapia-avancada-para-tratamento-de-cancer. Acesso em: 16 dez. 2023.
ALLEMANI, C. et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet, v.17, n.391, p.1023-1075, Mar 2018. doi: 10.1016/S0140-6736(17)33326-3. Acesso em: 16 dez. 2023.
AMERICAN CANCER SOCIETY. Cancer A-Z. Leukemia. Atlanta: American Cancer Society, 2022. Disponível em: https://www.cancer.org/cancer/leukemia.html. Acesso em: 16 dez. 2023.
ANDRADE, A.M. et al. A systematic review on the cost-effectiveness assessment of tisagenlecleucel for refractory or relapsing B-cell acute lymphoblastic leukemia (R/R B-ALL) treatment in children and young adults, v.25, n.9, p.930-938. 2023 Sep doi: 10.1016/j.jcyt.2023.05.011. Acesso em: 16 dez. 2023.
ANTUNES, J.L.F.; CARDOSO, M.R.A. Using time series analysis in epidemiological studies. Epidemiol Serv Saúde, v.24, n.3, p.565–76, sep 2015.
BASSAN, R.; HOELZER, D. Modern therapy of acute lymphoblastic leukemia. J Clin Oncol, v.1, n.29, p.532-43, 2011.
BISPO, J.A.B.; PINHEIRO, P.S.; KOBETZ, E.K. Epidemiology and Etiology of Leukemia and Lymphoma. Cold Spring Harb Perspect Med,v.10, n.6, p.a034819, jun 2020. doi: 10.1101/cshperspect.a034819. Acesso em: 16 dez. 2023.
BOQUIMPANI, C.M. et al. Inclusion of molecular monitoring (BCR-ABL1) in the treatment of chronic myeloid leukemia in the Brazilian Public Health System (SUS): an urgent need for treatment management. Hematol Transfus Cell Ther.v.43, n.1, p.50-57, jan-mar 2021. doi: 10.1016/j.htct.2020.02.002. Acesso em: 16 dez. 2023.
CEPPI, F. et al. Improvement of the outcome of relapsed or refractory acute lymphoblastic leukemia in children using a risk-based treatment strategy. PLoS One, v.1, n.11 ,p.e0160310, 2016.
CHATENOUD, L. et al. Childhood cancer mortality in America, Asia, and Oceania, 1970 through 2007. Cancer, v.116, n.21 ,p.5063-74, Nov 2010.
CHENNAMADHAVUNI, A.; LYENGAR, V.; SHIMANOVSKY, A. Leukemia. 2021 Nov 21. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
CODEPLAN- Federal District Planning Company. The area of influence of Brasília and the proposed expansion of the DF and surrounding area. Disponível em: https://www.codeplan.df.gov.br/wp-content/uploads/2018/03/%C3%81rea-de-Influ%C3%AAncia-de-Bras%C3%ADlia-e-Proposta-de-Amplia%C3%A7%C3%A3o-da-RIDE-do-DF-e-Entorno.pdf. Acesso em: 16 dez. 2023.
DISTRITO FEDERAL. Decreto No. 39,546, de 19 de dezembro de 2018. Internal Regulations of the State Department of Health of the Federal District. 2018. Disponível em: http://www.sinj.df.gov.br/sinj/Norma/c7d8594440ea48969cee564fafa77865/Decreto_39546_19_12_2018.html. Acesso em: 28 dez. 2023.
FERREIRA, D.F.L.G. et al. Morbidity and deaths due to leukemia in patients under 14 years. Journal of Nursing UFPE online, v.1, n.13, p.e237584. https://doi.org/10.5205/1981-8963.2019.237584. Acesso em: 16 dez. 2023.
GAVIDIA, R. et al. Low socioeconomic status is associated with prolonged times to assessment and treatment, sepsis and infectious death in pediatric fever in El Salvador, PLoS One; v.7, n.8, p. e43639, 2012.
GLOBO. Índice de não comparecimento de pacientes compromete saúde do DF. Disponível em: https://g1.globo.com/distrito-federal/noticia/2011/07/indice-de-nao-comparecimento-dos-pacientes-compromete-saude-do-df.html. Acesso em: 16 dez. 2023.
GOUVEIA, M.S. et al. Comparison of factors associated with leukemia and lymphoma mortality in Brazil. Public Health Notebooks, v.36, n.8, 2020. https://doi.org/10.1590/0102-311X00077119. Acesso em: 16 dez. 2023.
INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. IBGE | Cities | Federal District | Brasilia | Panorama. Disponível em: https://cidades.ibge.gov.br/brasil/df/brasilia/panorama. Acesso em: 16 jun. 2023.
INSTITUTO NACIONAL DO CÂNCER (INCA). Estimate 2023: incidence of cancer in Brazil / National Cancer Institute. – Rio de Janeiro: INCA, 2022a, 160p. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf. Acesso em: 16 dez. 2023.
INSTITUTO NACIONAL DO CÂNCER (INCA). 2020 estimate: incidence of cancer in Brazil / National Cancer Institute. – Rio de Janeiro: INCA, 2022b, 160p. Disponível em: https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf. Acesso em: 16 dez. 2023.
JORGE, M.H.; GOTLIEB, S.L.; LAURENTI, R. O sistema de informações sobre mortalidade: problemas e propostas para o seu enfrentamento I - Mortes por causas naturais. Revista Brasileira de Epidemiologia Rev Bras Epidemiol; v.1, n.5, p.197-211, ago 2002.
LI, Y. et al. Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population. Circulation, v.138, n.4, p.345-355, jul 2018. doi: 10.1161/CIRCULATIONAHA.117.032047. Acesso em: 16 dez. 2023.
MADER. H. Equipamentos que ficaram encaixotados or cinco anos começarão a funcionar no HUB. Correio Braziliense. Cidades. Disponível em: https://www.correiobraziliense.com.br/app/noticia/cidades/2009/07/24/interna_cidadesdf,129258/equipamentos-que-ficaram-encaixotados-or-cinco-anos-comecarao-a-funcionar-no-hub.shtml. Acesso em: 28 dez. 2023.
MORAIS, R. 13,8% dos remédios usados contra câncer estão em falta no DF. Disponível em: https://g1.globo.com/distrito-federal/noticia/2015/07/138-dos-remedios-usados-contra-cancer-estao-em-falta-no-df.html. Acesso em: 28 dez. 2023.
NATIONAL CANCER INSTITUTE -NIH. Leukemia. Disponível em: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/leukemia. Acesso em: 16 dez. 2023.
NUNES, S. dos S. et al. Sociodemographic and clinical profile of bone marrow transplant recipients: Reference Centers in Brazil and Spain. Research, Society and Development, v.9, n.5, p.e19952931, 2020. https://doi.org/10.33448/rsd-v9i5.2931. Acesso em: 16 dez. 2023.
PUI, C.H. et al. Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? Blood, v.120, n.6, p.1165-1174, 2012.
RIBERA, J.M.; ORIOL, A. Acute lymphoblastic leukemia in adolescents and young adults. Hematol Oncol Clin N Am, v.1, n.23, p.1033-42, 2009.
SAMRA, B. et al. Evolving therapy of adult acute lymphoblastic leukemia: State-of-the-art treatment and future directions. J Hematol Oncol, v.1, n.13 p.70, 2020.
SARAIVA, D. da C.A.; SANTOS, S. da S.; MONTEIRO, G.T.R. Trend in mortality from leukemia in children and adolescents in the capitals of Brazilian states: 1980-2015. Epidemiol Serv Saúde. v.27, n.3, p.e2017310. 2018. Disponível em: https://doi.org/10.5123/S1679-49742018000300004. Acesso em: 16 dez. 2023.
SILVA, F.F. da; LATORRE, M. do R.D. de O. Survival of acute lymphoid leukemias in children in the city of São Paulo, Brazil. Cad Public Health, v.36, n.3, p. e00008019, 2020. Disponível em: https://doi.org/10.1590/0102-311X00008019. Acesso em: 16 dez. 2023.
SILVA, M.G.P. et al. Trends in morbidity and mortality due to childhood cancer in an irrigated fruit growing hub. Collective health notebooks, v.1, n.26, p.38-44, 1999.
SMITH, O.P. Clinical characteristics and treatment of lymphoblastic leukemia. In: ARCECI, R.J. HISO (Ed.). Pediatric Hematology. Massachusetts: Blackwell Publishing, 2006. p. 450-481. Acesso em: 16 dez. 2023.
SOARES, M.R. et al. Mortality trends and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso. Rev bras epidemiol., v.1, n.25, p.e220008, 2022. Disponível em: https://doi.org/10.1590/1980-549720220008.supl.1. Acesso em: 16 dez. 2023.
STATA. Data analysis and statistical software, version 16. 2020.
VIANA, S.S. Mortality from acute lymphoblastic leukemia: results from a 35-year-old cohort in the northeast region of Brazil. Postgraduate Program in Health Sciences at the Federal University of Sergipe. Doctorate in Health Sciences, 2015.
WAR, R.D.O. et al. Early diagnosis of acute leukemia in children and adolescents. Revista de la Sociedad Boliviana de Pediatría, La Paz, v.54, n.2, p.110-115, 2015. Disponível em: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1024-06752015000200010. Acesso em: 16 dez. 2023.
WORLD HEALTH ORGANIZATION (WHO). ICD-10: International statistical classification of diseases and related health problems: tenth revision, 2nd ed. Geneva: World Health Organization; 2010.
WORLD HEALTH ORGANIZATION (WHO). Leukaemia Source: Globocan 2020. Disponível em: https://gco.iarc.fr/today/data/factsheets/cancers/36-Leukaemia-fact-sheet.pdf. Acesso em: 16 dez. 2023.
YI, M. et al. Global burden and trends of acute lymphoblastic leukemia from 1990 to 2017. Aging (Albany NY), v.12, n.22, p.22869-22891, Nov 2020. doi: 10.18632/aging.103982. Acesso em: 16 dez. 2023.
