Clinical and epidemiological aspects of head and neck cancer patients in a brazilian north-eastern oncology hospital: a retrospective study
Aspectos clínicos e epidemiológicos de pacientes com câncer de cabeça e pescoço em um hospital oncológico do nordeste brasileiro: um estudo retrospectivo
DOI:
https://doi.org/10.53660/CLM-3673-2403Palavras-chave:
Head and neck neoplasms, Mouth neoplasms, Squamous cell carcinomaResumo
The purpose of this study is to describe the head and neck cancer patients who are receiving treatment at an oncology facility in a state in northeastern Brazil. Fisher's Exact test was used to analyze the data, which were taken from medical records, tabulated, and statistically analyzed to see whether the factors and the disease result (death or remission) were related. P < 0.05 values were regarded as statistically significant. 74.4% of the 86 medical records that were examined were male, 89% of them were over 40, and 38.4% of them involved smoking. The tongue was the most common anatomical site of cancer (36%). Surgery was the most often used treatment approach (44.2%). A poorer prognosis was linked to the existence of distant metastases (p = 0.041). Compared to individuals with cancer in the oral cavity and maxillary sinus, those with cancer in the nasopharynx, larynx, and oropharynx had a better prognosis (p=0.002). Men of mixed ethnicity, over 40, and mostly with tongue lesions made up the patient profile. The majority of patients had advanced clinical stages at diagnosis, and 47.7% of the sample perished.
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Referências
ABRAHÃO, R. et al. Predictors of Survival After Head and Neck Squamous Cell Carcinoma in South America: The InterCHANGE Study. JCO Global Oncology, n. 6, p. 486–499, nov. 2020.
ADJEI BOAKYE, E. et al. Multilevel Associations Between Patient- and Hospital-Level Factors and In-Hospital Mortality Among Hospitalized Patients with Head and Neck Cancer. JAMA Otolaryngology–Head & Neck Surgery, v. 146, n. 5, p. 444, 1 maio 2020.
ADJEI BOAKYE, E. et al. Factors Associated with Head and Neck Cancer Hospitalization Cost and Length of Stay—A National Study. American Journal of Clinical Oncology, v. 42, n. 2, p. 172–178, fev. 2019.
AHMED, S. et al. Oral squamous cell carcinoma under microscopic vision: A review of histological variants and its prognostic indicators. SRM Journal of Research in Dental Sciences, v. 10, n. 2, p. 90, 2019.
CLINTON, S. K.; GIOVANNUCCI, E. L.; HURSTING, S. D. The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: Impact and Future Directions. The Journal of Nutrition, v. 150, n. 4, 23 nov. 2019.
CONWAY, D. I.; PURKAYASTHA, M.; CHESTNUTT, I. G. The changing epidemiology of oral cancer: definitions, trends, and risk factors. British Dental Journal, v. 225, n. 9, p. 867–873, nov. 2018.
DE MORAIS, E. F. et al. Prognostic Factors of Oral Squamous Cell Carcinoma in Young Patients: A Systematic Review. Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, v. 75, n. 7, p. 1555–1566, 1 jul. 2017.
FERLAY, J. et al. Cancer Statistics for the Year 2020: an Overview. International Journal of Cancer, v. 149, n. 4, 5 abr. 2021.
GORMLEY, M. et al. Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. British Dental Journal, v. 233, n. 9, p. 780–786, 1 nov. 2022.
ILHAN, B.; GUNERI, P.; WILDER-SMITH, P. The contribution of artificial intelligence to reducing the diagnostic delay in oral cancer. Oral Oncology, v. 116, p. 105254, maio 2021.
KHODE, S. R. et al. Exploring the link between human papilloma virus and oral and oropharyngeal cancers. Journal of Cancer Research and Therapeutics, v. 10, n. 3, p. 492, 1 jul. 2014.
KOUKA, M. et al. The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany. Cancers, v. 15, n. 6, p. 1780, 15 mar. 2023.
MAHL, C.; SANTOS, A. D. DOS; LIMA, S. V. M. A. Tendência Temporal e Distribuição Espacial da Mortalidade por Câncer de Boca em Sergipe. Revista Brasileira de Cancerologia, v. 68, n. 2, 10 jun. 2022.
MARTÍNEZ, C. et al. Frecuencia de displasia epitelial y carcinoma escamoso en mucosa oral y orofaríngea en Chile, entre los años 1990 y 2009. Revista médica de Chile, v. 144, n. 2, p. 169–174, fev. 2016.
MEHANNA, H. et al. Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis. The Lancet Oncology, v. 24, n. 3, p. 239–251, mar. 2023.
Ministério da Saúde Instituto Nacional de Câncer José Alencar Gomes da Silva Ministério da Saúde Instituto Nacional de Câncer. [s.l: s.n.]. Disponível em: <https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2023.pdf>.
MORO, J. DA S. et al. Oral and oropharyngeal cancer: epidemiology and survival analysis. Einstein (São Paulo), v. 16, n. 2, 7 jun. 2018.
NATIONAL CANCER INSTITUTE, 2020. Cancer of the Tongue - Cancer Stat Facts. Disponível em: <https://seer.cancer.gov/statfacts/html/tongue.html>.
OSAZUWA-PETERS, N. et al. Sexual behavior, HPV knowledge, and association with head and neck cancer among a high-risk group. Oral Oncology, v. 51, n. 5, p. 452–456, maio 2015.
O’SULLIVAN, B. et al. The TNM classification of malignant tumours—towards common understanding and reasonable expectations. The Lancet Oncology, v. 18, n. 7, p. 849–851, jul. 2017.
SANTOS, E. B. DOS; COLACITE, J. Avaliação epidemiológica do câncer de cabeça e pescoço no Brasil: mortalidade e fatores de risco regionais. Saúde e Pesquisa, v. 15, n. 3, p. 1–15, 1 jul. 2022.
SILVA, C. M. G. et al. Tobacco and Alcohol Use and Clinical Staging of Head and Neck Tumors. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, v. 20, 2020.
SUNG, H. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a Cancer Journal for Clinicians, v. 71, n. 3, p. 209–249, 4 fev. 2021.
TRANBY, E. P. et al. Oral Cancer Prevalence, Mortality, and Costs in Medicaid and Commercial Insurance Claims Data. Cancer Epidemiology, Biomarkers & Prevention, v. 31, n. 9, p. 1849–1857, 22 jun. 2022.
WORLD HEALTH ORGANIZATION: REGIONAL OFFICE FOR EUROPE. WORLD CANCER REPORT: cancer research for cancer development. [s.l: s.n.].
ZHANG, L.-W. et al. Incidence and mortality trends in oral and oropharyngeal cancers in China, 2005–2013. Cancer Epidemiology, v. 57, p. 120–126, dez. 2018.
