Maternal and fetal outputs in pregnant women with severe pre-eclampsy diagnosis
Débito materno e fetal em gestantes com diagnóstico de pré-eclâmpsia grave
Palavras-chave:
Pregnancy complications, Pre-eclampsia, Obstetric Delivery, Fetal ViabilityResumo
This study aims to evaluate maternal and perinatal outcomes among cases of planned and emergency cesarean section in PE with severe features. Retrospective cohort study with 202 women diagnosed with severe pre-eclampsia, with gestational age greater than 32 weeks. They were divided according to the mode of delivery: vaginal delivery, planned cesarean section and emergency cesarean section. Were analyzed the sociodemographic characteristics, obstetric history and clinical conditions at admission, post operatory maternal and perinatal outcomes and complications according to the type mode of delivery. A total 202 patients were included in the study, 78.7% of whom underwent planned cesarean section, 21.3% emergency cesarean sections and only 11.8% induced labor was performed and of the total. Only 2% of total progressed to vaginal delivery. Patients living in the interior (53.5%, P 0.040), primiparous (OR 1.4, P <0.001), history of previous pre-eclampsia (OR 1.3, P = 0.020) and presence of signs of severity (OR 10.1, P <0.001) had a higher risk of evolving to an emergency cesarean section. Postpartum hemorrhage was greater in the programmed cesarean section (OR 2.4, P 0.049). Regarding perinatal complications, the time of fetal hospitalization in days was longer in the programmed cesarean section (OR 6.7, P 0.035). These results demonstrate that there is a high rate of indication for cesarean sections (98%) in patients with severe preeclampsia. A high rate of cesarean section does not positively affect the indicators of maternal and neonatal morbidity and mortality. In addition, in women in whom delivery was induced, there was no increase in neonatal risks..
Downloads
Referências
ACOG (American College of Obstetricians and Gynecologists). Committee eon Practice Bulletins-Obstetrics. Chronic hypertension in pregnancy. Obstet. Gynecol. 98 (1), suppl 177-85, 2013. DOI: 10.1016/s0029-7844(01)01471-5
Alanis MC, Robinson CJ, Hulsey TC, Ebeling M, Johnson DD. Early‐onset severe preeclampsia: induction of labor vs elective cesarean delivery and neonatal outcomes. American Journal of Obstetrics and Gynecology 2008;199(3):262.e1‐262.e6 DOI: 10.1016/j.ajog.2008.06.076
Amorim MMR, Katz L, Barros AS, Almeida TSF, Souza ASR, Faúndes A. Maternal outcomes according to mode of delivery in women with severe preeclampsia: a cohort study, The Journal of Maternal-Fetal E Medicina Neonatal. 2015 28: (6), 654-660. DOI: 10.3109/14767058.2014.928689
Amorim MMR, Souza AR, Katz L. Planned caesarean section versus planned vaginal birth for severe pre-eclampsia. Cochrane Database of Systematic Reviews 2017, Issue 10. Art. DOI: 10.1002/14651858.CD009430.pub2
Antunes MB et al. Hypertensive syndrome and perinatal outcomes in high-risk pregnancies. Rev Min Enferm. 2017; 21: e-1057 DOI: 10.5935/1415-2762.20170067.
Appropriate technology for birth. Lancet.1985; 2 (8452):436-7. Available: https://www.ncbi.nlm.nih.gov/pubmed/2863457
Boerma L, Ronsmans C, Melesse DY, Aluisio JDB, Juan FCBL, et al. Global epidemiology of use of and disparities in caesarean sections. The Lancet. V. 392, N. 10155, P1341-1348, Published: October 13, 2018. DOI: 10.1016/S0140-6736(18)31928-7
Botelho NM, Silva IFMM, Tavares JR, Lima LO. Causes of maternal death in Pará State, Brazil. Rev. Bras. Ginecol. Obstet. [Internet]. 2014 July; 36(7): 290-295. Available: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000700290&lng=en.
Brasil, Ministério da Saúde. Gestação de alto risco. Série A. Normas e manuais técnicos. Secretaria de atenção à saúde. Departamento de Atenção Básica. Manual técnico 5ª edição: Brasília- DF, 2013. Available: https://bvsms.saude.gov.br/bvs/publicacoes/gestacao_alto_risco.pdf
Chaim SRP; Oliveira SMJV; Kimura AF. Pregnancy-induced hypertension and the neonatal outcome. Acta paul. enferm. [online]. 2008, 21(1): 53-58. https://doi.org/10.1590/S0103-21002008000100008
Giordano JC, Parpinelli MA, Cecatti JG, Haddad SM, Costa ML, Surita FG, et al. The burden of eclampsia: results from a multicenter study on surveillance of severe maternal morbidity in Brazil. PLoS One. 2014;9(5):e97401. orbidity in Brazil. PLoS One 2014;9:e97401. DOI: http://dx.doi.org/10.1371/journal.pone.0097401
Gonzales GF, Tapia VL, Fort AL, Betran AP. Pregnancy outcomes associated with Cesarean deliveries in Peruvian public health facilities. Int J Womens Health. 2013; 5: 637-45. DOI: 10.2147/IJWH.S46392
Hansen AK, Wisborg K, Uldbjerg N, Henriksen TB. Risk of respiratory morbidity in term infants delivered by elective caesarean section: cohort study. BMJ. 2008;336(7635):85–87. DOI: 10.1136/bmj.39405.539282.BE
Hazelgrove JF, Price C, Pappachan VJ, Smith GB. Multicenter study of obstetric admissions to 14 intensive care units in southern England. Crit Care Med, 2001; 29(4): 770-775. doi: 10.1097/00003246-200104000-00016.
Hernández-díaz, s.; toh, s.; cnattingius, s. Riskofpre-eclampsia in firs tandsu bsequent pregnancies: prospective cohort study. BMJ. 2009;338: b2255 DOI: 10.1136/bmj.b2255
Herstad L, Klungsoyr K, Skjærven R, Tanbo T, Forsén L, Åbyholm T et al. Elective cesarean section or not? Maternal age and risk of adverse outcomes at term: a population-based registry study of low-risk primiparous women. BMC Pregnancy and Childbirth [serial on the Internet]. 2016;16(230):1-11. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988032/
Kawakita T, Bowers K. Maternal and neonatal outcomes of induction of labor compared with planned cesarean delivery in women with preeclampsia at 34 weeks' gestation or longer. American Journal of Perinatology 2017 August 24; 10:935‐40. DOI: 10.1055/s-0037-1606185
Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367(9516):1066-74. Available: https://www.ncbi.nlm.nih.gov/pubmed/16581405
Linhares JJ, Macêdo NMQ, Arruda GM, Vasconcelos JLM, Saraiva TV, Ribeiro AF. Fatores associados à via de parto em mulheres com pré-eclâmpsia. Rev. Bras. Ginecol. Obstet. [Internet]. 2014 June; 36(6): 259-263. Available: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032014000600259&lng=en
Nassar AH, Adra AM, Chakhtoura N, Gómez-Marín O, Beydoun S. Severe preeclampsia remote from term: labor induction or elective cesarean delivery? Am J Obstet Gynecol. 1998;179(5):1210-3. DOI: 10.1016/s0002-9378(98)70133-4
Nomura RMY, Alves EA, ZM. Maternal complications associated with type of delivery in a university hospital. Rev. Saúde Pública [Internet]. 2004 Feb [cited 2020 Mar 30] ; 38(1): 9-15. DOI: https://doi.org/10.1590/S0034-89102004000100002.
Oliveira ACM, Santos AA, Bezerra AR, Barros AMR, Machado Tavares MC Maternal Factors and Adverse Perinatal Outcomes in Women with Preeclampsia in Maceió, Alagoas. Arq Bras Cardiol. 2016; ahead print, PP.0-0. https://doi.org/10.5935/abc.20150150
Oliveira LG, Karumanchi A, Sass N. Preeclampsia: oxidative stress, inflammation and endothelial dysfunction. Rev. Bras. Ginecol. Obstet. [Internet]. 2010 Dec; 32 (12): 609-616. Available: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032010001200008&lng=en.
Pádua KS, Osis MJD, Faúndes A, Barbosa AH, Moraes FOB Factors associated with cesarean sections in Brazilian hospitalss. Rev. Saúde Pública. 2010 Feb; 44(1): 70-79. Available: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102010000100008&lng=en.
Palacio MA; Botello ML. Resultados perinatales en la preeclampsia con signos de gravedad. Revista cubana de Obstetricia y Ginecología. 2011; 37(2):147-153. Available: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0138-600X2011000200004
Peraçoli JC, Borges VT, Ramos JG, Cavalli RC, Costa SH, Oliveira LG, et al. Pré-eclâmpsia/ eclâmpsia. São Paulo: Federação Brasileira das Associações de Ginecologia e Obstetrícia (Febrasgo); 2018. Available: https://www.febrasgo.org.br/media/k2/attachments/REVISTAZFEMINAZ-Z2019ZVOLZ47ZNZ5.pdf
Santos VB; Pancera TR, Albuquerque IC, Corrêia RGF. Infecção de sítio cirúrgico em mulheres submetidas à cesariana em uma maternidade pública. Rev Pesq Saúde, 2017; 18(1): 35-40, jan-abr,. Available: http://www.periodicoseletronicos.ufma.br/index.php/revistahuufma/article/view/7878.
Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785-99. DOI: 10.1016/S0140-6736(05)17987-2 DOI: 10.3109/14767058.2014.928689
Vogel JP, Betrán AP, Vindevoghel N, Souza JP, Torloni MR, Zhang J et al. On behalf of the WHO Multi-Country Survey on Maternal and Newborn Health Research Network. Use of the Robson classification to assess caesarean section trends in 21 countries: a secondary analysis of two WHO multicountry surveys. Lancet Global Health 2015;3(5):e260-70. DOI: 10.1016/S2214-109X(15)70094-X
World Health Organization. Report on the World Health Organization Working Group on the Classification of Maternal Deaths and Severe Maternal Morbidities. Geneva: WHO, 2009 doi: 10.2471/BLT.09.071001
Ye J, Betrán AP, Guerrero Vela M, Souza JP, Zhang J. Searching for the optimal rate of medically necessary cesarean delivery. Birth. 2014;41(3):237-244. DOI: 10.1111/birt.12104
Ye J, Zhang J, Mikolajczyk R, Torloni MR, Gülmezoglu AM, Betran AP. Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. BJOG. 2016;123(5):745-753. DOI: 10.1111/1471-0528.13592
Yücesoy G, Özkan S, Bodur H. et al. Resultado materno e perinatal em gestações complicadas com transtorno hipertensivo da gravidez: uma experiência de sete anos em um centro de atendimento terciário. Arch Gynecol Obstet 273, 43–49 (2005). https://doi.org/10.1007/s00404-005-0741-3.
Zhang WH, Alexander S, Bouvier-Colle MH, Macfarlane A. Incidence of severe pre-eclampsia, postpartum haemorrhage and sepsis as a surrogate marker for severe maternal morbidity in a European population-based study: the MOMS-B survey. BJOG. Jan 2005;112:89-96. DOI: 10.1111/j.1471-0528.2004.00303.x