Oral lichen planus and systemic diseases: casual association or causal?
Líquen plano oral e doenças sistêmicas: associação casual ou causal?
Palavras-chave:
Oral lichen planus, Systemic diseases, Chronic diseases, etiopathogenesisResumo
Lichen planus (LP) is a chronic inflammatory disease, mediated by T cells, with a multifactorial etiology, being associated with various diseases and systemic conditions. The objectives of this study are to determine, through the analysis of the literature, the casuistic or causal relationship in the concomitant presentation of Oral Lichen Planus (OLP) and other systemic diseases, and to analyze a series of cases treated at the University Hospital of Brasília (HUB) between 2015 and 2020. Methodology: This study was developed through a review of the literature published between 2016 and 2022, relating systemic diseases with OLP and the analysis of series of OLP cases treated at the HUB. Results: The review showed evidence of the relationship between OLP and Thyroid Disease (TD), Psychiatric Disease (PD), HPV virus and oxidative stress. Furthermore, it was observed that alterations in the oral bacterial microbiota are associated with the progression of OLP. Analysis of the case series identified a relationship between TD and PD with OLP. Conclusion: It is observed that there is strong evidence of the relationship between OLP and DT, DP, HPV virus, oxidative stress and the presence of periodontal bacteria in the oral cavity.
Downloads
Referências
AGHA-HOSSEINI, F. et al. Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review. Journal of Islamic Dental Association of IRAN, v. 31, n. 1, p. 40–57, 2019.
AGHBARI, S. M. H. et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncology, v. 68, p. 92–102, 2017.
ALAIZARI, N. A. et al. Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis. Australian Dental Journal, v. 61, n. 3, p. 282–287, 2016.
ALAMIR, A. W. H. et al. Association of nitric oxide with oral lichen planus. Journal of Oral Pathology and Medicine, v. 48, n. 5, p. 345–350, 2019.
ALIKHANI, M. et al. Association between the clinical severity of oral lichen planus and anti-TPO level in thyroid patients. Brazilian Oral Research, v. 31, 2017.
ALRASHDAN, M. S.; CIRILLO, N.; MCCULLOUGH, M. Oral lichen planus: a literature review and update. Archives of Dermatological Research, v. 308, n. 8, p. 539–551, 2016.
ARANEDA, S. et al. Probable Association Between Oral Lichen Planus and presence of Helicobacter Pylori : A Preliminary Study in a Chilean Population. International journal of odontostomatology, v. 14, n. 1, p. 131–135, mar. 2020.
ARDUINO, P. G. et al. Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: A hint for endocrinologists. Endocrine Connections, v. 6, n. 8, p. 726–730, 2017.
BAEK, K.; CHOI, Y. The microbiology of oral lichen planus: Is microbial infection the cause of oral lichen planus? Molecular Oral Microbiology, v. 33, n. 1, p. 22–28, 2018.
BARROS, M. B. DE A. et al. Relato de tristeza/depressão, nervosismo/ansiedade e problemas de sono na população adulta brasileira durante a pandemia de COVID-19. Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil, v. 29, n. 4, p. e2020427, 2020.
BATU, Ş. et al. Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions. Journal of Oral Pathology and Medicine, v. 45, n. 4, p. 281–288, 2016.
BIKLE, D. D. Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry and Biology, v. 21, n. 3, p. 319–329, 2014.
CARROZZO, M. et al. Tumor Necrosis Factor-α and Interferon-γ Polymorphisms Contribute to Susceptibility to Oral Lichen Planus. Journal of Investigative Dermatology, v. 122, n. 1, p. 87–94, 2004.
CASSOL-SPANEMBERG, J. et al. Oral lichen planus and its relationship with systemic diseases. A review of evidence. Journal of clinical and experimental dentistry, v. 10, n. 9, p. e938–e944, 2018.
CERQUEIRA, J. D. M. et al. Psychological disorders and oral lichen planus: A systematic review. Journal of investigative and clinical dentistry, v. 9, n. 4, p. e12363, 2018.
CHAITANYA, N. et al. Systematic meta-analysis on association of human papilloma virus and oral cancer. Journal of Cancer Research and Therapeutics, v. 12, n. 2, p. 969–974, 2016.
CHOI, Y. S. et al. The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus. Scientific Reports, v. 6, n. December 2015, p. 1–13, 2016.
DE LIMA, S. L. G. et al. Clinicopathologic data of individuals with oral lichen planus: A Brazilian case series. Journal of Clinical and Experimental Dentistry, v. 11, n. 12, p. 1–11, 2019.
DEANGELIS, L. M.; CIRILLO, N.; MCCULLOUGH, M. J. The immunopathogenesis of oral lichen planus—Is there a role for mucosal associated invariant T cells? Journal of Oral Pathology and Medicine, v. 48, n. 7, p. 552–559, 2019.
DIDONA, D. et al. Therapeutic strategies for oral lichen planus: State of the art and new insights. Frontiers in Medicine, v. 9, n. Il, 2022.
DONEMPUDI, P. et al. Association of oral lichen planus with hepatitis C virus, surface antigen of hepatitis B virus, and diabetes: A clinical and biochemical study. Journal of Indian Academy of Oral Medicine and Radiology, v. 28, n. 3, p. 256, 2016.
DU, G. HUAN et al. Potential association between Fusobacterium nucleatum enrichment on oral mucosal surface and oral lichen planus. Oral Diseases, v. 26, n. 1, p. 122–130, 2020.
GARCIA-POLA, M. J. et al. Thyroid Disease and Oral Lichen Planus as Comorbidity: A Prospective Case-Control Study. Dermatology, v. 232, n. 2, p. 214–219, 2016.
GILLISON, M. L. et al. Prevalence of Oral HPV Infection in the United States, 2009-2010. J. American Medical Association, v. 307, n. 7, 2012.
GONZÁLEZ-MOLES, M. Á. et al. Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis. Oral Oncology, v. 96, n. May, p. 121–130, 2019.
HASAN, S. et al. Oral lichen planus and associated comorbidities: An approach to holistic health. Journal of Family Medicine and Primary Care, v. 8, n. 11, p. 3504, 2019.
HIROTA, S.; MARUI, S.; MIGLIARI, D. Does autoimmune thyroid disorder act as a predisposing factor in the development of oral lichen planus? Oral Diseases, v. 26, n. 6, p. 1337–1339, 2020.
HUMBERTO, J. S. M. et al. Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: a systematic review. Brazilian oral research, v. 32, p. e82, 2018.
IDREES, M. et al. Oral lichen planus has a very low malignant transformation rate: A systematic review and meta-analysis using strict diagnostic and inclusion criteria. Journal of Oral Pathology and Medicine, v. 00, n. January, p. 1–12, 2020.
ISMAIL, S. B.; KUMAR, S. K. S.; ZAIN, R. B. Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation. Journal of oral science, v. 49, n. 2, p. 89–106, 2007.
KARTHIKEYAN, P.; ASWATH, N. Stress as an etiologic co-factor in recurrent aphthous ulcers and oral lichen planus. Journal of Oral Science, v. 58, n. 2, p. 237–240, 2016.
KATS, L. et al. Oral lichen planus and thyroid gland diseases: possible associations. BMC oral health, v. 19, n. 1, p. 169, 2019.
LI, C. et al. Global Prevalence and Incidence Estimates of Oral Lichen Planus: A Systematic Review and Meta-Analysis. JAMA Dermatology, v. 156, n. 2, p. 172–181, 2020.
LOPEZ-JORNET, P. et al. Evaluation of the salivary level of cortisol in patients with oral lichen planus: A meta-analysis. Medicina (Lithuania), v. 55, n. 5, p. 213–217, 2019.
MA, J. et al. The MAGNITUDE OF THE ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS AND ORAL LICHEN PLANUS: A META-ANALYSIS. PLoS ONE, v. 11, n. 8, 2016.
MERHY, R. et al. Pediatric lichen planus: a systematic review of 985 published cases. International Journal of Dermatology, v. 61, n. 4, p. 416–421, 2022.
MESTER, A. et al. Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis c virus (HCV)-related OLP. Bosnian Journal of Basic Medical Sciences, v. 18, n. 3, p. 217–223, 2018.
MITRAN, M. I. et al. Reactive Carbonyl Species as Potential Pro-Oxidant Factors Involved in Lichen Planus Pathogenesis. Metabolites, v. 9, n. 10, 2019.
MOHD HANAFIAH, K. et al. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology, v. 57, n. 4, p. 1333–1342, 2013.
MOSTAFA, D.; MOUSSA, E.; ALNOUAEM, M. Evaluation of photodynamic therapy in treatment of oral erosive lichen planus in comparison with topically applied corticosteroids. Photodiagnosis and Photodynamic Therapy, v. 19, p. 56–66, 2017.
MOZAFFARI, H. R. et al. Evaluation of serum and salivary interferon-γ levels in patients with oral lichen planus: a systematic review and meta-analysis of case-control studiesOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2019.
MUTAFCHIEVA, M. Z. et al. Oral Lichen Planus - Known and Unknown: a Review. Folia medica, v. 60, n. 4, p. 528–535, 2018.
NOSRATZAHI, T.; RAIESI, M.; SHAHRYARI, B. Lack of association between oral lichen planus and hepatitis B and C virus infection - A report from southeast Iran. Asian Pacific Journal of Cancer Prevention, v. 19, n. 6, p. 1633–1637, 1 jun. 2018.
OTERO-REY, E. M. ARI. et al. Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression? Acta odontologica Scandinavica, v. 72, n. 8, p. 570–577, 2014.
ROBLEDO-SIERRA, J.; VAN DER WAAL, I. How general dentists could manage a patient with oral lichen planus. Medicina Oral Patologia Oral y Cirugia Bucal, v. 23, n. 2, p. e198–e202, 2018.
SAMEERA, A. et al. Molecular Detection of Human Papillomavirus DNA in Oral Lichen Planus Patients. Journal of Clinical and Diagnostic Research, v. 13, n. 1, 2019.
SHAH, S. M. Association of Oral Lichen Planus With Hepatitis-C and Diabetes Mellitus. Pakistan Oral & Dental Journal, v. 36, n. 1, p. 35–38, 2016.
SHANG, Q. et al. Association of Human Papillomavirus With Oral Lichen Planus and Oral Leukoplakia: A Meta-analysis. Journal of Evidence-Based Dental Practice, v. 20, n. 4, p. 101485, 2020.
SHAVIT, E.; KLIEB, H.; SHEAR, N. H. Oral lichen planus: A novel staging and algorithmic approach and all that is essential to knowF1000Research, 2020.
SHIVA, A. et al. Serum and Salivary Level of Nitric Oxide (NOx) and CRP in Oral Lichen Planus (OLP) Patients. Journal of Dentistry (Shiraz University of Medical Sciences), v. 21, n. 1, p. 6–11, 2020.
SUGERMAN, P. B. et al. The pathogenesis of oral lichen planusCritical Reviews in Oral Biology and Medicine, 2002.
TANG, Y. et al. A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China. Frontiers in endocrinology, v. 10, p. 928, 2019.
TÓTHOVÁ, L. et al. Salivary markers of oxidative stress in oral diseases. Frontiers in Cellular and Infection Microbiology, v. 5, n. OCT, p. 1–23, 2015.
TVARIJONAVICIUTE, A. et al. Evaluation of salivary oxidate stress biomarkers, nitric oxide and C-reactive protein in patients with oral lichen planus and burning mouth syndrome. Journal of Oral Pathology and Medicine, v. 46, n. 5, p. 387–392, 1 maio 2017.
VADIVEL, J. K. et al. Mast cell expression in oral lichen planus: A systematic review. Journal of investigative and clinical dentistry, v. 10, n. 4, p. e12457, 2019.
VALTER, K. et al. The influence of psychological state on oral lichen planus. Acta Clinica Croatica, v. 52, n. 2, p. 145–150, 2013.
VAN DER WAAL, I. Oral lichen planus and oral lichenoid lesions; a critical appraisal with emphasis on the diagnostic aspects. Medicina Oral, Patologia Oral y Cirugia Bucal, v. 14, n. 7, p. 310–314, 2009.
VANDERPUMP, M. P. J. The epidemiology of thyroid disease. British Medical Bulletin, v. 99, n. 1, p. 39–51, 2011.
VEHVILÄINEN, M. et al. No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism. Acta Odontologica Scandinavica, v. 78, n. 5, p. 337–344, 2020.
VILAR-VILLANUEVA, M. et al. Psychological disorders and quality of life in oral lichen planus patients and a control group. Oral Diseases, v. 25, n. 6, p. 1645–1651, 2019.
WANG, J.; VAN DER WAAL, I. Disease scoring systems for oral lichen planus; a critical appraisal. Medicina Oral, Patologia Oral y Cirugia Bucal, v. 20, n. 2, p. e199–e204, 2015.
WANG, X. et al. Microbial Community Analysis of Saliva and Biopsies in Patients With Oral Lichen Planus. Frontiers in Microbiology, v. 11, n. May, p. 1–12, 2020.
WU, P. et al. Possible Mechanisms Involved in the Cooccurrence of Oral Lichen Planus and Hashimoto’s ThyroiditisMediators of InflammationHindawi Limited, , 2020. Disponível em: <https://pubmed.ncbi.nlm.nih.gov/32089646/>. Acesso em: 19 out. 2020
XIA, D. N. et al. Omega-3 polyunsaturated fatty acids: a promising approach for the management of oral lichen planus. Inflammation Research, v. 69, n. 10, p. 989–999, 2020.
ZHOU, T. et al. Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study. Frontiers in endocrinology, v. 9, n. JUN, p. 330, 2018.
