HLA-I allelic variants related to resistance and susceptibility to severe SARS-CoV-2 infection

Variantes alélicas do HLA I relacionados a resistência ou suscetibilidade a infecção grave pelo SARS-CoV-2

Autores

Palavras-chave:

Pandemias, Coronavirus, Antígenos HLA

Resumo

Objective: Identify allelic variants of HLA I related to possible resistance or susceptibility to severe SARS-CoV-2 infection and describe this relationship. Methods: This study is a descriptive literature review based on articles published between the years 2020 and 2021 in the databases: SciELO, ScienceDirect, PubMed /MEDLINE, Capes Periodicals, BVS, Wiley Online Library; that was available in Brazilian Portuguese and English. Results: The analyzed studies demonstrated that HLA I alleles can be considered like determinants of resistance or susceptibility to COVID-19 due to their ability to bind to SARS-CoV-2 peptides, influencing in the regulation of the immune response against the SARS-CoV-2 virus. Conclusions: There is an agreement between the authors regarding the role of HLA I like a determinant of resistance and genetic susceptibility to SARS-CoV-2, where the HLA-B*46:01 was the most cited (20% frequency) as allele that confers susceptibility to the virus, and HLA-A *02: 01 and HLA-A *31: 01 were the most cited among the alleles that may confer protection against the most severe infection of COVID-19 (frequency of 19% and 18 % respectively).

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Referências

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Publicado

2023-04-01

Edição

2023: Transformative Actions

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Articles