Extravasation due by anthracyclines: an oncology emergency
Extravasamento por antraciclinas: uma emergência oncológica
Resumo
This article aims to describe the mechanism of action of anthracyclines, prevention and treatment strategies for extravasation of these drugs. A search was carried out in electronic databases. The number ofextravasations occurred in a chemotherapy unit is considered an indicator of nursing care quality. Risk reduction and proper management of extravasation are in line with safe drug administration, which is aninternational patient safety goal. Thus, nursing care in relation to the infusion of anthracyclines via peripheral intravenous route, as well as the complications arising fromthis oncological emergency, are crucial for the improvement of nursing care. Knowledgeabout strategies for the prevention and managementof extravasation by anthracyclines is essential for nurses.
Downloads
Referências
ADAMI, N. P. et al. Extravasamento de Drogas Antineoplásicas: Notificação e Cuidados Prestados. Revista Brasileira de Cancerologia, v. 47, n. 2, p. 143–151, 29 jun. 2001.
AL-BENNA, S.; O'BOYLE, C.; HOLLEY, J. Extravasation injuries in adults. ISRN Dermatology, e-856541. 2013
BARTAL A, MÁTRAI Z, ROSTA A, SZÛCS A. Introduction of a clinical protocol for extravasation at the National Institute of Oncology, Budapest, Hungary. Magy Onkol. 2011 Mar;55(1):14-20. Hungarian. Epub 2011 Mar 31. PMID: 21617787.
BERTOGLIO, S. et al. Improving outcomes of short peripheral vascular access in oncology and chemotherapy administration. The Journal of Vascular Access, v. 18, n. 2, p. 89–96, 21 mar. 2017.
BONASSA, E.M.A.; GATO, M.I.R. Terapêutica Oncológica para enfermeiros e farmacêuticos, 4ª ed. São Paulo: Editora Atheneu, 2012.
BRUNHEROTTI, M. R. Intervenções no extravasamento de quimioterápicos vesicantes: revisão integrativa da literatura. 2007. Dissertação (Mestrado em Enfermagem Fundamental) - Escola de Enfermagem de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 2007. doi:10.11606/D.22.2007.tde-13082007-102108. Acesso em: 2022-09-30
BRUNO, M. L. M. et al. Condutas de enfermagem no extravasamento de quimioterápicos antineoplásicos: protocolo operacional padrão. Revista de Enfermagem UFPE online, v. 8, n. 4, p. 974–980, 30 mar. 2014.
CEPSP, CEPO, BOULANGER et al. Management of the extravasation of anti-neoplastic agents. Supportive Care in Cancer, v. 23, n. 5, p. 1459–1471, maio 2015.
CUSTÓDIO, C. S. et al. Evaluation of a peripheral vein for intravenous chemotherapy: a prospective observational study. Enfermería Global, v. 21, n. 2, p. 28–45, 1 abr. 2022.
ENEH, C.; LEKKALA, M.R. Dexrazoxane. 2022 Aug 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
FIDALGO, J. A. P. et al. Management of chemotherapy extravasation: ESMO–EONS clinical practice guidelines. European Journal of Oncology Nursing, v. 16, n. 5, p. 528–534, 2012.
FRANCO, J. N. et al. Percepção da equipe de enfermagem sobre fatores causais de erros na administração de medicamentos. Revista Brasileira de Enfermagem, v. 63, p. 927–932, dez. 2010. https://doi.org/10.1590/S0034-71672010000600009
FREITAS, K.A.B.S.; ROCHA, N.S.; MINICUCCI, E.M.; SILVA, V.F.B.; LANGONI, H.; POPIM, R.C. Effects of photobiomodulation on wound contraction in rats undergoing doxorubicin extravasation: a histomorphometric analysis. Rev Esc Enferm USP. 2021;55:e20200527. DOI: https://doi.org/10.1590/1980-220X-REEUSP-2020-0527.
FREITAS, K. A. B. S.; LIMA, T. O.; MINICUCCI, E. M.; VIGLIASSI, A.P.; POPIM, R. C. Associação da fotobiomodulação e da hialuronidase tópica no extravasamento e infiltração de antineoplásicos. Estudo retrospectivo. Nursing (São Paulo), v. 23, n. 271, p. 4971–4978, 2020. DOI: 10.36489/nursing.2020v23i271p4971-4978. Disponível em: https://revistas.mpmcomunicacao.com.br/index.php/revistanursing/article/view/1045. Acesso em: 29 out. 2022.
FREITAS, K.A.B.S.; MINICUCCI, E.M.; SILVA, V.F.B.; MENOZZI, B.D.; LANGONI, H.; POPIM, R.C. Effects of photobiomodulation (660 nm laser) on anthracycline extravasation: an experimental study. Rev. Latino-Am. Enfermagem. 2022; 30:e3693. [Out, 29,2022] Available in: https://doi.org/10.1590/1518-8345.5786.3693
FREITAS, K.A.B.S.; POPIM, R. Manual de extravasamento de antineoplásicos 2. ed. rev. e ampl. – Botucatu: FMB/HC, 2021 Disponível em: http://www.hcfmb.unesp.br/biblioteca-virtual
GORSKI, LA et al. Infusion Therapy Standards of Practice. 8th edition revised. Infusion Nursing Society. 2021
GOOLSBY, T. V.; LOMBARDO, F. A. Extravasation of Chemotherapeutic Agents: Prevention and Treatment. Seminars in Oncology, v. 33, n. 1, p. 139–143, fev. 2006.
GOZZO, T. O.; ALMEIDA, T. D. DE; CRUZ, L. A. P. DA. Notificação de extravasamento de agentes quimioterápicos em um hospital universitário. Ciência, Cuidado e Saúde, v. 17, n. 2, 13 jul. 2018.
JORDAN, K.; GROTHE, W.; SCHMOLL, H. J. Extravasation of chemotherapeutic agents: prevention and therapy. Deutsche Medizinische Wochenschrift (1946), v. 130, n. 1–2, p. 33–37, 7 jan. 2005.
KATZUNG, B. G.; TREVOR, A. J. Farmacologia básica e clínica. Porto Alegre: AMHG Editora, 2017. E-book. 9788580555974.
KREIDIEH, F.Y.; MOUKADEM, H.A.; EL SAGHIR, N.S. Overview, prevention and management of chemotherapy extravasation. World J Clin Oncol. 2016 Feb 10;7(1):87-97. doi: 10.5306/wjco.v7.i1.87.
KIM, J.T.; PARK, J.Y; LEE, H.J.; CHEON, Y.J. Guidelines for the management of extravasation. J Educ Eval Health Prof. 2020, vol.17, pg 21.
LIMA, R. F. Elaboração e validação do manual de orientações sobre reações adversas a antineoplásicos para a equipe de enfermagem. 2019. Dissertação (Mestrado Profissional). Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Programa de Pós-graduação em Pesquisa Clínica, Porto Alegre, 2019.
MELO, J. M. A. et al. Prevention and conduct against the Extravasation of antineoplastic chemotherapy: a scoping review. Revista Brasileira de Enfermagem, v. 73, 17 jun. 2020. https://doi.org/10.1590/0034-7167-2019-0008.
MIURA, N. O.; AUNG, N. Y.; YAMAKAWA, M. Effect of cold and hot compress on neutrophilic migration to the site of doxorubicin extravasation. International Journal of Clinical and Experimental Pathology, v. 12, n. 4, p. 1468–1477, 1 abr. 2019.
MOUREAU, N.; CHOPRA, V. Indications for peripheral, midline and central catheters: summary of the MAGIC recommendations. British Journal of Nursing (Mark Allen Publishing), v. 25, n. 8, p. S15-24, 28 maio 2016.
NAVARRO-ULLOA, O. D. et al. Muerte súbita debida a cardiotoxicidad aguda inducida por antraciclinas. Rev. colomb. cardiol, p. 80–80, 2018.
NEDOMANSKY, J. et al. Tissue distribution of epirubicin after severe extravasation in humans. Cancer Chemotherapy and Pharmacology, vol. 88, p. 203-209, 2021.
PAUKOVCEKOVA, S. et al. Thiosemicarbazones Can Act Synergistically with Anthracyclines to Downregulate CHEK1 Expression and Induce DNA Damage in Cell Lines Derived from Pediatric Solid Tumors. International Journal of Molecular Sciences, v. 23, n. 15, p. 8549, 1 ago. 2022.
POLOVICH, M.; OLSEN, M.; LEFEBVRE, K.B. Chemotherapy and Biotherapy Guidelines and recommendations for practice. 4a ed. Oncology Nursing Society: pg 155-160. January 17, 2014.
PRAKASH, P. et al. Effectiveness of structures teaching programme on knowledge regardin management of extravasation of chemotherapeutic drugs. Insights Depress Anxiety, vol. 6, p. 18-24.
REZENDE, G. M. R.; LINO, A. I. DE A.; MORAIS, T. C. P. Assistência de Enfermagem aos pacientes com extravasamento de medicamentos antineoplásicos: revisão integrativa. Com. Ciências Saúde, p. 69–76, 2021.
REVANNASIDDAIAH, S. et al. Local toxicity of antracycline extravasation. BMJ case reports, v. 2013, p. bcr2013009711, 22 maio 2013. doi:10.1136/ bcr-2013-009711
SAUERLAND, C. et al. Vesicant extravasation part I: Mechanisms, pathogenesis, and nursing care to reduce risk. Oncology Nursing Forum, v. 33, n. 6, p. 1134–1141, 27 nov. 2006.
SILVA, S. M. O. et al. Levantamento dos índices de extravasamento de quimioterápicos no ambulatório de quimioterapia do Centro de Assistência de Alta Complexidade de Oncologia (CACON) – HUPAA. Gep News, v. 1, n. 1, p. 172–177, 2 abr. 2018.
SOUZA, N. R. et al. Oncological emergency: the work of nurses in the extravasation of antineoplastic chemotherapeutic drugs. Escola Anna Nery, v. 21, 16 jan. 2017.
WENGSTRÖM, Y.; MARGULIES, A. European Oncology Nursing Society Task Force. European Oncology Nursing Society extravasation guidelines. European Journal of Oncology Nursing: The Official Journal of European Oncology Nursing Society, v. 12, n. 4, p. 357–361, set. 2008.