Canine cutaneous mastocytoma: case report
Palavras-chave:
Dog, Histamine, Mast cell, Neoplasia, TumorResumo
Mast cell tumor is a neoplasm with a high incidence in dogs, whose etiopathogenesis and etiology are poorly understood. Originating from the neoplastic proliferation of mast cells, they can be observed in the skin, mainly in the dermis, subcutaneous tissue, or in other organs. The tumors are often solitary, have a varied appearance and size and do not show a predilection for sex, but are observed with a higher incidence in breeds such as Golden Retriever and others. Treatment will depend on the degree of histopathological classification, tumor staging and patient prognosis. The objective of this case report was to describe the complete treatment of a neutered female dog, nine years and ten months old, Golden Retriever with high-grade mast cell tumor (III). The animal presented enlargement of the right mandibular lymph node and subcutaneous nodules, of firm consistency, attached to the right cervical region and without changes in hematological examinations. After an increase in tumor mass, cytoreductive chemotherapy with vinblastine was started, followed by nodulectomy of the right cervical region and supportive therapy. Since there has been no positive response, euthanasia was performed. Correct diagnosis helps in deciding on clinical and therapeutic management, ensuring better patient life support. However, the dog in this report had treatment unfeasible due to the diagnosis of a high-grade tumor that reduced her survival time.
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Referências
American Society of Anesthesiologists. ASA Physical Status Classification. Park Ridge, IL: American Society of Anesthesiologists, 2010.
ALBERTUS, JCC. Tratar a un paciente con cancer. In. ALBERTUS, JCC. Manuales clínicos por especialidades. Oncología veterinária. España: Servet, 2011, p. 29.
AVERY, A. Diagnóstico Molecular de Câncer Hematológico. In. THRALL, AM, et al. Hematologia e Bioquímica Clínica Veterinária. 2.ed. Rio de Janeiro: Guanabara Koogan, 2017.
BAUMER, W. Histamina, Serotonina e seus Antagonistas. In. RIVIERE, JE., et al. Adams Booth: farmacologia e terapêutica veterinária. 10ª ed. Rio de Janeiro: Guanabara Koogan, 2021, p. 362-364.
BENZONANA, LL et al. Isoflurane, a commonly used volatile anesthetic, enhances renal cancer growth and malignant potential via the hypoxia-inducible factor cellular signaling pathway in vitro. Anesthesiology. v.119, n.3, p.593-605, 2013.
BLACKWOOD L et al. European consensus document on mast cell tumours in dogs and cats. Veterinary Comparative Oncology. v.10, n.3, p.e1-e29, 2012.
BOSTOCK, DE. Neoplasms of the skin and subcutaneous tissues in dogs and cats. British Veterinary Journal. v.42, p.1–19, 1986.
COGLIATI. B. Patologia Geral das Neoplasias. In. JERICÓ, MM; ANDRADE NETO, JP & KOGIKA, MM. Tratado de Medicina Interna de Cães e Gatos. 1ª ed. Rio de Janeiro: Rocca, 2015.
COUTO, CG. Cytology. In. Nelson, RW. & Couto, CG. Small Animal Internal Medicine. 6th ed. St. Louis, Missouri: Elsevier, 2020. p. 1257.
______. Practical Chemotherapy. In. Nelson, RW. & Couto, CG. Small Animal Internal Medicine. 6th ed. St. Louis, Missouri: Elsevier, 2020. p. 1269.
______. Selected Neoplasms in Dogs and Cats. In. Nelson, RW. & Couto, CG. Small Animal Internal Medicine. 6th ed. St. Louis, Missouri: Elsevier, 2020. p. 1328 - 1333.
DE NARDI, AB. Oncologia. In. CRIVELLENTI, LZ & BORIN-CRIVELLENTI, S. Casos de rotina em medicina veterinária de pequenos animais. 2ª ed. São Paulo: Editora MedVet Ltda, 2015, p. 749.
DE NARDI, AB; FILHO, NPR & VIERA, R.B. Quimioterapia antineoplásica. In. DALECK, CR & DE NARDI, AB. Oncologia em cães e gatos. 2ª ed. Rio de Janeiro: Rocca, 2016, p.366.
DALECK, CR; ROCHA, NS & FERREIRA, MGPA. Mastocitoma. In. DALECK, CR & DE NARDI, AB. Oncologia em cães e gatos. 2ª ed. Rio de Janeiro: Rocca, 2016, p. 955-968.
FUKUMASU, H et al. Patologia Molecular das Neoplasias. In. JERICÓ, MM; ANDRAADE NETO, JPA & KOGIKA, MM. Tratado de Medicina Interna de Cães e Gatos. 1ª ed. Rio de Janeiro: Rocca, 2015, p.1519 – 1520.
GERARDI, DG. Mecanismo de Resistência aos Quimioterápicos. In. DALECK, CR & DE NARDI, AB. Oncologia em cães e gatos. 2ª ed. Rio de Janeiro: Rocca, 2016, p. 366.
GILL V, LEIBMAN N, MONETTE S, CRAFT DM, BERGMAN PJ. Prognostic indicators and clinical outcome in dogs with subcutaneous mast cell tumors treated with surgery alone: 43 cases. Journal of the American Animal Hospital Association. 2020;56(4):215-25.
HOENIG, M. Medicamentos que Influenciam o Metabolismo da Glicose. In. RIVIERE, JE et al. Adams Booth: farmacologia e terapêutica veterinária. 10ª ed. Rio de Janeiro: Guanabara Koogan, 2021, p.612-620.
HONG, J.Y. Effects of metoclopramide and ranitidine on preoperative gastric contents in day-case surgery. Yonsei Medical Journal, v.47, p.315-318, 2006.
KIUPEL, M et al. Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior. Veterinary Pathology, v.48, p. 147-155, 2011.
KUKANICH, BM & PAPICH, MG. Analgésicos Opioides. In. RIVIERE, JE., et al. Adams Booth: farmacologia e terapêutica veterinária. 10ª ed. Rio de Janeiro: Guanabara Koogan, 2021, p. 612-620.
LONDON, C.A & THAMM, DH. Mast Cell Tumors. In. THAMM, DH; VAIL, DM & LIPTAK, JM. Withrow & MacEwen’s Small Animal Clinical Oncology. 6th ed. St. Louis, Missouri: Elsevier, 2020, p.382.
LUCIDI, CA & MARCELLO, GCG. Abordagem às Citopenias. In. JERICÓ, MM; ANDRAADE NETO, JPA & KOGIKA, MM. Tratado de Medicina Interna de Cães e Gatos. 1ª ed. Rio de Janeiro: Rocca, 2015, p. 5604-5605.
MARCELLO, VT et al. Epidemiologia e Etiologia do Câncer. In. DALECK, CR & DE NARDI, AB. Oncologia em cães e gatos. 2ª ed. Rio de Janeiro: Rocca, 2016, p.36.
MORENO, JCD. et al. Manejo da Dor no Paciente com Câncer. In. DALECK, CR & DE NARDI, AB. Oncologia em cães e gatos. 2ª ed. Rio de Janeiro: Rocca, 2016, p.454-474.
PATNAIK, AK; EHLER, WJ & MACEWEN, EG. Canine Cutaneous Mast Cell Tumor: Morphologic Grading and Survival Time in 83 Dogs. Veterinary Pathology. v. 21, p. 469-474, 1984.
RANGEL, F; SIMÕES, CM & AULER JUNIOR, J.O.C. Anestesia no paciente oncológico: as técnicas e agentes anestésicos podem influenciar o desfecho destes pacientes. Revista de Medicina da USP. v.99, n.1, p. 40-45, 2020.
ROTHWELL, TLW et al. Skin neoplasms of dogs in Sydney. Australian Veterinary Journal. v.64, p.161-164, 1987.
SAKLAD, M. Grading of patients for surgical procedures. ASA Publications Anesthesiology. v. 2, p. 281-284, 1941.
TAKAHIRA, RK. Defeitos Hemostáticos Secundários. In. JERICÓ, MM; ANDRADE NETO, JPA & KOGIKA, MM. Tratado de Medicina Interna de Cães e Gatos. 1ª ed. Rio de Janeiro: Rocca, 2015.
