Alzheimer's disease: therapeutic potential of phytocannabinoids

Doença de Alzheimer: potencial terapêutico dos fitocanabinoide

Autores

Resumo

Alzheimer's Disease is a progressive neurodegenerative condition that results in cognitive decline and behavioral changes. This article aims to analyze the therapeutic potential of phytocannabinoids in Alzheimer's Disease. We conducted a systematic search of articles published from 2014 to May 2024 in the MEDLINE (PubMed), LILACS, and SCOPUS databases, using terms related to Alzheimer's Disease, neuroinflammation, endocannabinoid system, phytocannabinoids, cannabis, cannabinoid, cannabidiol, and delta-9-tetrahydrocannabinol. The results of this systematic review provide a comprehensive overview of the interaction between neurodegeneration and the endocannabinoid system, highlighting the potential of phytocannabinoids as therapeutic interventions for Alzheimer's Disease.

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Biografia do Autor

Terezinha Carla Carvalho da Silva, Universidade Federal Rural de Pernambuco

Doutoranda em Biociência Animal pela Universidade Federal Rural de Pernambuco, na linha de pesquisa Mecanismos de ação de compostos naturais ou sintéticos em processos funcionais patológicos. Pesquisadora bolsista CAPES em doenças neurodegenerativas e ação dos fitocanabinoides sobre o sistema nervoso. Mestre em Medicina Veterinária pela Universidade Federal Rural de Pernambuco

Anderson Ramos da Silva , Universidade Federal Rural de Pernambuco

Médico Veterinário graduado pela Universidade Federal Rural de Pernambuco

Caroline Helena da Silva Campagnone, Centro Universitário Monte Serrat

Possui Graduação em Medicina Veterinária pelo Centro Universitário São Judas Tadeu - Campus UNIMONTE (2016). Atualmente é Diretora de Equipe Veterinária do Centro Veterinário Cãopagnone, Diretora Geral da Associação Medicinal de Canábica - AME-C 

Antônio José Alves, Universidade Federal de Pernambuco

Doutor em ciência Farmaceutica e professor Titular da UFPE

Valdemiro Amaro da Silva Junior , Universidade Federal Rural de Pernambuco

Graduado em Medicina Veterinária pela Universidade Federal Rural de Pernambuco (UFRPE), Especialista em Morfologia Humana pela Universidade Federal de Pernambuco (UFPE), Doutor em Biologia Celular pela Universidade Federal de Minas Gerais com Pós-Doutorado realizado na Universidade da Geórgia, Athens-EUA no Departamento de Patologia da Faculdade de Medicina Veterinária. Atualmente é Professor Titular da patologia veterinária na Universidade Federal Rural de Pernambuco, Pesquisador 1 D CNPQ, participa dos programas de pós-graduação em Biociência Animal do Departamento de Morfologia e Fisiologia Animal (UFRPE) e Biotecnologia Renorbio (UFRPE), Desenvolvimento e Inovação Tecnológica em Medicamentos (UFRPE) e do programa de Pós-Graduação de Biologia Aplicada a Saúde UPE (LICA). Atualmente, trabalha com as seguintes linhas de pesquisa: 1) Patologia Experimental com ênfase no desenvolvimento de novos fármacos e terapias experimentais; 2) Fitocanabinóides medicinais: tratamento de doenças neurológicas, neurodegenerativas e inflamatórias induzidas experimentalmente.

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2024-08-14

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2024: Sustainable Pathways

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