Comparative study between two surgical techniques in the treatment and reconstruction of non-melanoma skin tumors
Estudo comparativo entre duas técnicas cirúrgicas de pequena e média complexidade, no tratamento e reconstrução de tumores cutâneos não melanoma
Resumo
Non-melanoma skin tumors (NMSC), predominantly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most common skin cancers. Despite generally having lower lethality compared to melanoma, their high incidence represents a significant cost to healthcare systems. The main risk factor is exposure to ultraviolet radiation, along with fair skin phenotype, genetic predisposition, age, and immunosuppression. Diagnoses are based on clinical examination, dermatoscopy, histopathology, and immunohistochemistry. The gold standard treatment is surgical excision with safety margins. This study compares the efficacy and safety of two surgical techniques in the treatment and reconstruction of NMSC. The results were based on descriptive and quantitative analysis, association/correlation of the studied variables, histological subtypes, and reconstruction techniques. POSAS and Vancouver scales were used for study validation. Histological subtypes were important for the objectives of these techniques as well as their safety margins.
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Referências
Sexton, M., Jones, D. B., & Maloney, M. E. (1990). Histologic Pattern Analysis Of Basal Cell Carcinoma. Journal Of The American Academy Of Dermatology, 23(6), 1118–1126. Doi:10.1016/0190-9622(90)70344-H
Narayanan, D. L., Saladi, R. N., & Fox, J. L. (2010). Ultraviolet Radiation And Skin Cancer. *International Journal Of Dermatology*, 49(9), 978-986. Doi:10.1111/J.1365-4632.2010.04474.X
Rogers, H. W., Weinstock, M. A., Feldman, S. R., & Coldiron, B. M. (2015). Incidence Estimate Of Nonmelanoma Skin Cancer In The United States, 2006. *Archives Of Dermatology*, 146(3), 283-287. Doi:10.1001/Archdermatol.2010.19
Epstein, E. H. (2008). Basal Cell Carcinomas: Attack Of The Hedgehog. *Nature Reviews Cancer*, 8(10), 743-754. Doi:10.1038/Nrc2503
Brash, D E Et Al. Sunlight And Sunburn In Human Skin Cancer: P53, Apoptosis, And Tumor Promotion. The Journal Of The Investigative Dermatology. Symposium Proceedings. [S.I.], P. 136-142. Ago. 1996.
Kittler, H., Et Al. (2002). Diagnostic Accuracy Of Dermoscopy. *The Lancet Oncology*, 3(3), 159-165. Doi:10.1016/S1470-2045(02)00679-4
Habif, T. P., Et Al. (2017). *Skin Disease: Diagnosis And Treatment*. Elsevier Health Sciences.
Rajadhyaksha, M., Et Al. (1999). Confocal Laser Microscope Imaging Of Skin In Vivo: Comparison Of Reflectance Mode Images With Histology. *Journal Of Investigative Dermatology*, 113(3), 293-303. Doi:10.1046/J.1523-1747.1999.00690.
Martinez, Marcos Antonio Rodrigues; Francisco, Guilherme; CabraL, Luciana Sanches; RUIZ, Itamar Romano Garcia; Festa Neto, Cyro. Genética Molecular Aplicada Ao Câncer Cutâneo Não Melanoma. Anais Brasileiros De Dermatologia, [S.L.], V. 81, N. 5, P. 405-419, Out. 2006. Fapunifesp (Scielo). Http://Dx.Doi.Org/10.1590/S0365-05962006000500003.
Https://Www.Nccn.Org/Professionals/Physician_Gls/Pdf/Nmsc.Pdf
Instituto Nacional De Câncer (INCA). (2020). Estimativa 2020: Incidência De Câncer No Brasil. Retrieved From https://www.inca.gov.br
Sullivan, T., Smith, J., Kermode, J., Mciver, E., & Courtemanche, D. J. (1990). Rating The Burn Scar. Journal Of Burn Care & Rehabilitation, 11(3), 256-260.
Ota A S, Magalhães F, Furtado G P, Garcia E B, Ferreira L M. Validação Da Versão Em Português Dp Patient Scar Assessment Questionnaire. Revista Brasileira De Cirurgia Plástica. 2022 Sep 13;(0631)
Nahhas A F, Scarbrough C A, Trotter S. A Review Of The Global Guidelines On Surgical Margins For Nonmelanoma Skin Cancers. Journal Of Clinical And Aesthetic Dermatology. 2017 Abril/2017;10
Lee K S, Kim J O, Kim N G, Lee Y J, Park Y J, Kim J S. A Comparison Of The Local Flap And Skin Graft By Location Of Face In Reconstruction After Resection Of Facial Skin Cancer. Archives Of Craniofacial Surgery. 2017 Dec 05;18:255-260
Mamsen, F.P.W.; Kiilerich, C.H.; Hesselfeldt-Nielsen, J.; Saltvig, I.; Remvig, C.L.-N.; Trøstrup, H.; Schmidt, V.-J. Risk Stratification Of Local Flaps And Skin Grafting In Skin Cancer-Related Facial Reconstruction: A Retrospective Single-Center Study Of 607 Patients. J. Pers. Med. 2022, 12, 2067. Https://Doi.Org/10.3390/ Jpm12122067