Effect of probiotic supplementation in murines with induced osteoporosis: systematic review with meta-analysis
Efeito da suplementação de probiótico em murinos com osteoporose induzida: revisão sistemática com meta-análise
Palavras-chave:
Bone, Bifidobacterium, Ovariectomized, Rats, MiceResumo
Postmenopausal osteoporosis results in low bone mineral density, interference in bone microarchitecture, decreased bone strength, and an increased risk of fragility fractures. This systematic review aimed to increase the level of evidence on supplementation with bacteria of the genus Bifidobacterium in induced osteoporosis in murines, rats, and ovariectomized female mice (OVX). The search was initially conducted using the PubMed, Embase, ScienceDirect, Scopus, Web of Science, and Scielo databases in 2024, using the keywords “osteoporosis”, “murine”, “ovariectomized”, “OVX”, and “Bifidobacterium”. In total, 89 full articles, abstracts, or book chapters were found and after detailed screening, 5 studies met the inclusion criteria, using 66 animals, randomly divided between control and treatment groups. The results demonstrated that oral supplementation with bacteria of the genus Bifidobacterium significantly improves parameters indicative of bone health BMD, BMC, BV/TV%, and Tb.Sp. In conclusion, this meta-analysis provides evidence that bacteria of the genus Bifidobacterium are involved in anti-osteoporotic mechanisms in female OVX rats and mice, as a preclinical model, and suggests the need for further studies in postmenopausal women as a therapeutic alternative or complementary therapy to conventional osteoporosis treatments.
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ABDUL-MAJEED, S.; MOHAMED, N.; SOELAIMAN, I.-N. The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy. Life Sciences, v. 125, p. 42–48, 15 mar. 2015.
AIBAR-ALMAZÁN, A. et al. Current Status of the Diagnosis and Management of Osteoporosis. International Journal of Molecular Sciences, v. 23, n. 16, p. 9465, 21 ago. 2022.
ARANTES, H. P.; SILVA, A. G. DA; LAZARETTI-CASTRO, M. Bisphosphonates in the treatment of metabolic bone diseases. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 54, n. 2, p. 206–212, mar. 2010.
ARTONI DE CARVALHO, J. A. et al. Prebiotics improve osteoporosis indicators in a preclinical model: systematic review with meta-analysis. Nutrition Reviews, v. 81, n. 8, p. 891–903, 10 jul. 2023.
BEHERA, J. et al. The role of gut microbiota in bone homeostasis. Bone, v. 135, p. 115317, 1 jun. 2020.
CAI, H. et al. BMP2 induces hMSC osteogenesis and matrix remodeling. Molecular Medicine Reports, v. 23, n. 2, p. 125, 8 dez. 2020.
CHUGH, B.; KAMAL-ELDIN, A. Bioactive compounds produced by probiotics in food products. Current Opinion in Food Science, v. 32, p. 76–82, 1 abr. 2020.
COLLINS, F. L. et al. The Potential of Probiotics as a Therapy for Osteoporosis. In: BRITTON, R. A.; CANI, P. D. (Eds.). . Bugs as Drugs. [s.l.] NIH Public Access, 2017. v. 5p. 213–233.
COMPSTON, J. E.; MCCLUNG, M. R.; LESLIE, W. D. Osteoporosis. The Lancet, v. 393, n. 10169, p. 364–376, jan. 2019.
DAMANI, J. J. et al. The Role of Prunes in Modulating Inflammatory Pathways to Improve Bone Health in Postmenopausal Women. Advances in Nutrition, v. 13, n. 5, p. 1476–1492, 2 set. 2022.
DAVIS, E. C. et al. Microbiome Composition in Pediatric Populations from Birth to Adolescence: Impact of Diet and Prebiotic and Probiotic Interventions. Digestive Diseases and Sciences, v. 65, n. 3, p. 706–722, 31 mar. 2020.
DE SIRE, A. et al. Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis. Cells, v. 11, n. 4, p. 743, 21 fev. 2022.
GROUP ON HORMONAL FACTORS IN BREAST CANCER, C. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. The Lancet, v. 394, n. 10204, p. 1159–1168, 28 set. 2019.
HAMILTON, S.; TERENTYEV, D. Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart. International Journal of Molecular Sciences, v. 20, n. 10, p. 2386, 14 maio 2019.
HEANEY, R. P. Calcium intake and disease prevention. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 50, n. 4, p. 685–693, ago. 2006.
HELGASON, B. et al. Mathematical relationships between bone density and mechanical properties: A literature review. Clinical Biomechanics, v. 23, n. 2, p. 135–146, fev. 2008.
IBÁÑEZ, L. et al. Gut microbiome and bone. Joint Bone Spine, v. 86, n. 1, p. 43–47, 1 jan. 2019.
JIA, L. et al. Probiotics ameliorate alveolar bone loss by regulating gut microbiota. Cell Proliferation, v. 54, n. 7, 7 jul. 2021.
KALU, D. N. The ovariectomized rat model of postmenopausal bone loss. Bone and mineral, v. 15, n. 3, p. 175–91, dez. 1991.
KEEN, M. U.; REDDIVARI, A. K. R. Osteoporosis In Females. [s.l.] StatPearls Publishing, 2023.
KEMI, V. E.; KÄRKKÄINEN, M. U. M.; LAMBERG-ALLARDT, C. J. E. High phosphorus intakes acutely and negatively affect Ca and bone metabolism in a dose-dependent manner in healthy young females. British Journal of Nutrition, v. 96, n. 3, p. 545–552, 17 set. 2006.
KHOSLA, S.; HOFBAUER, L. C. Osteoporosis treatment: recent developments and ongoing challenges. The Lancet Diabetes & Endocrinology, v. 5, n. 11, p. 898–907, nov. 2017.
KRAUTH, D.; WOODRUFF, T. J.; BERO, L. Instruments for Assessing Risk of Bias and Other Methodological Criteria of Published Animal Studies: A Systematic Review. Environmental Health Perspectives, v. 121, n. 9, p. 985–992, set. 2013.
LEGETTE, L. L. et al. Prebiotics Enhance Magnesium Absorption and Inulin-based Fibers Exert Chronic Effects on Calcium Utilization in a Postmenopausal Rodent Model. Journal of Food Science, v. 77, n. 4, p. 88–94, abr. 2012.
LEGRAND, E. et al. Trabecular Bone Microarchitecture, Bone Mineral Density, and Vertebral Fractures in Male Osteoporosis. Journal of Bone and Mineral Research, v. 15, n. 1, p. 13–19, 1 jan. 2000.
LI, J.-Y. J.-Y. et al. Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics. Journal of Clinical Investigation, v. 126, n. 6, p. 2049–2063, 25 abr. 2016.
LI, S. et al. Gut microbiome and osteoporosis. Bone & Joint Research, v. 9, n. 8, p. 524–530, 1 ago. 2020.
LYU, Z. et al. Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis. Bone Research, v. 11, n. 1, p. 31, 9 jun. 2023.
MACLEOD, M. R. et al. Risk of Bias in Reports of In Vivo Research: A Focus for Improvement. PLOS Biology, v. 13, n. 10, p. e1002273, 13 out. 2015.
MADISON, A.; KIECOLT-GLASER, J. K. Stress, depression, diet, and the gut microbiota: human–bacteria interactions at the core of psychoneuroimmunology and nutrition. Current Opinion in Behavioral Sciences, v. 28, n. 2, p. 105–110, ago. 2019.
MATHEY, J. et al. Modulation of soy isoflavones bioavailability and subsequent effects on bone health in ovariectomized rats: the case for equol. Osteoporosis International, v. 18, n. 5, p. 671–679, 29 mar. 2007.
MCCABE, L.; BRITTON, R. A.; PARAMESWARAN, N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Current Osteoporosis Reports, v. 13, n. 6, p. 363–371, 30 dez. 2015.
MITEK, T. et al. Genetic Predisposition for Osteoporosis and Fractures in Postmenopausal Women. In: Advances in experimental medicine and biology. [s.l.] Adv Exp Med Biol, 2019. v. 1211p. 17–24.
MOHER, D. et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, v. 4, n. 1, p. 1, 1 dez. 2015.
MONTAZERI-NAJAFABADY, N. et al. Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss. Probiotics and Antimicrobial Proteins, v. 11, n. 4, p. 1145–1154, 17 dez. 2019.
MONTAZERI-NAJAFABADY, N. et al. Exploring the bone sparing effects of postbiotics in the post-menopausal rat model. BMC Complementary Medicine and Therapies, v. 21, n. 1, p. 155, 28 dez. 2021.
NIELSEN, D. S. et al. Case Study of the Distribution of Mucosa-Associated Bifidobacterium Species, Lactobacillus Species, andOther Lactic Acid Bacteria in the HumanColon. Applied and Environmental Microbiology, v. 69, n. 12, p. 7545–7548, dez. 2003.
NOVRIADI, R. et al. Well‐defined multispecies probiotic and enzyme combination outperforms traditional fermented probiotic applications in an intensive Pacific white shrimp, Litopenaeus vannamei (Boone, 1931), culture system. Journal of the World Aquaculture Society, v. 54, n. 1, p. 156–166, 24 fev. 2023.
PARVANEH, K. et al. Probiotics ( Bifidobacterium longum ) Increase Bone Mass Density and Upregulate Sparc and Bmp-2 Genes in Rats with Bone Loss Resulting from Ovariectomy. BioMed Research International, v. 2015, p. 1–10, 2015.
RADOMINSKI, S. C. et al. Diretrizes brasileiras para o diagnóstico e tratamento da osteoporose em mulheres na pós‐menopausa. Revista Brasileira de Reumatologia, v. 57, p. 452–466, 2017.
RIBEIRO, N. et al. Role of SPARC in Bone Remodeling and Cancer‐Related Bone Metastasis. Journal of Cellular Biochemistry, v. 115, n. 1, p. 17–26, 14 jan. 2014.
ROBERTS, J. L. et al. Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae. Biomedicine & Pharmacotherapy, v. 132, p. 110831, dez. 2020.
ROBERTS, J. L. et al. Bifidobacterium longum supplementation improves age‐related delays in fracture repair. Aging Cell, v. 22, n. 4, p. 1–17, 27 abr. 2023.
ROONEY, A. M. et al. PTH Treatment Increases Cortical Bone Mass More in Response to Compression than Tension in Mice. Journal of Bone and Mineral Research, v. 38, n. 1, p. 59–69, 12 jan. 2023.
SALARI, N. et al. The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research, v. 16, n. 1, p. 609, 17 out. 2021.
SAPRA, L. et al. Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory B Cells (Bregs). Frontiers in Immunology, v. 13, 25 maio 2022.
SHIM, K.-S. et al. Lactobacillus fermentation enhances the inhibitory effect of Hwangryun-haedok-tang in an ovariectomy-induced bone loss. BMC Complementary and Alternative Medicine, v. 13, n. 1, p. 106, 16 dez. 2013.
SŁUPSKI, W.; JAWIEŃ, P.; NOWAK, B. Botanicals in Postmenopausal Osteoporosis. Nutrients, v. 13, n. 5, p. 1609, 11 maio 2021.
SRIVASTAVA, R. K. et al. World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO-IOF-ESCEO 2022). Aging Clinical and Experimental Research, v. 34, n. S1, p. 35–474, 26 ago. 2022.
TREVISAN, C. et al. The Impact of Smoking on Bone Metabolism, Bone Mineral Density and Vertebral Fractures in Postmenopausal Women. Journal of Clinical Densitometry, v. 23, n. 3, p. 381–389, 1 jul. 2020.
TSVETOV, G. et al. Denosumab-induced hypocalcemia in patients with osteoporosis: can you know who will get low? Osteoporosis International, v. 31, n. 4, p. 655–665, 14 abr. 2020.
WEAVER, C. M. Parallels Between Nutrition and Physical Activity: Research Questions in Development of Peak Bone Mass. Research Quarterly for Exercise and Sport, v. 86, n. 2, p. 103–106, 3 abr. 2015.
XU, X. et al. Intestinal microbiota: a potential target for the treatment of postmenopausal osteoporosis. Bone Research, v. 5, n. 1, p. 17046, 4 out. 2017.
YAMAMOTO, K. et al. Symptoms and Upper Gastrointestinal Mucosal Injury Associated with Bisphosphonate Therapy. Internal Medicine, v. 58, n. 8, p. 1049–1056, 15 abr. 2019.
ZACARÍAS, M. F. et al. Effects of conventional and nonconventional drying on the stability of Bifidobacterium animalis subsp. lactis INL1. International Journal of Dairy Technology, v. 73, n. 3, p. 625–633, 9 ago. 2020.
