Vaginal microbiota and fertility: an integrative review
Microbiota vaginal e fertilidade: uma revisão integrativa
DOI:
https://doi.org/10.53660/CLM-3650-24M39Palavras-chave:
Dysbiosis, Infertility, VaginaResumo
The vaginal microbiota is made up of countless microorganisms that help to make it healthy and resistant to invasion by pathobionts, and studies suggest that there is an association between fertility and the balance/unbalance of this microenvironment. The aim of this study was to learn more about the vaginal microbiota and its influence on female (in)fertility. This is an integrative review guided by the steps of the PRISMA flowchart, searching for scientific articles in the BVS, Nature, PubMed and Scielo databases published in the years 2018-2022, in Portuguese, English and Spanish. Inclusion and exclusion criteria were used, and they were categorized into levels of evidence. This review consisted of twelve articles which show that vaginal dysbiosis causes changes in the metabolome of this environment, triggering inflammatory activation, which impacts on female fertility. In this sense, there is a need for further research into the interaction of microorganisms with each other and with male gametes, in eubiosis and vaginal dysbiosis, in order to facilitate or restrict their passage to the uterus and achieve successful fertilization.
Downloads
Referências
ATA, B.; YILDIZ, S.; TURKGELDI, E.; BROCAL, V.P.; DINLEYICI, E.C.; MOYA, A.; URMAN, B. The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Scientific Reports. v. 9, n. 1, 2019.
BALLE, C.; LENNARD, K.; DABEE, S.; BARNABAS, S.L.; JAUMDALLY, S.Z.; GASPER, M.A.; MASEKO, V.; MBULAWA, Z.Z.A.; WILLIAMSON, A.; BEKKER, L.; LEWIS, D.A.; PASSMORE, J.S.; JASPAN, H.B. Endocervical and vaginal microbiota in South African adolescents with asymptomatic Chlamydia trachomatis infection. Scientific Reports, v. 8, n. 1, 2018.
BULLINGTON, B. W.; MYUNG, LEE, M.H.; MLINGI, J.; PAUL, N.; ARISTIDE, C.; FONTANA, E.; LITTMANN, E.R.; MUKEREBE, C.; SHIGELLA, P.; KASHANGAKI, P.; KALLUVYA, S.E.; DE DOOD, C.J.; VAN DAM, G.J.; CORSTJENS, P.J.A.M.; FITZGERALD, D.W.; PAMER, E.G.; DOWNS, J.A. Cervicovaginal bacterial communities in reproductive-aged Tanzanian women with Schistosoma mansoni, Schistosoma haematobium, or without schistosome infection. ISME J, v. 15, p. 1539–1550, 2021.
CECCARANI, C.; FOSCHI, C.; PAROLIN, C.; D’ANTUONO, A.; GASPARI, V.; CONSOLANDI, C.; LAGHI, L.; CAMBONI, T.; VITALI, B.; SEVERGNINI, M.; MARANGONI, A. Diversity of vaginal microbiome and metabolome during genital infections. Scientific Reports, v. 9, n. 1, p. 14095, 2019.
CHALLA, A.; KACHHAWA G.; SOOD S.; UPADHYAY A.D.; DWIVEDI S.N.; GUPTA S. Correlates of bacterial vaginosis among women from North India. International journal of STD & AIDS, v. 33, n. 7, p. 666-671, 2022.
ESCALDA, C.; BOTELHO J.; MENDES J.J.; MACHADO V. Association of bacterial vaginosis with periodontitis in a cross-sectional American nationwide survey. Scientific Reports, v. 11, 2021.
GHOLIOF, M; ADAMSON-DE LUCA, E; WESSELS, J. M. The female reproductive tract microbiotas, inflammation, and gynecological conditions. Front Reprod Health, 2022.
JAKOBSEN, R. R.; HAAHR T.; HUMAIDAN P.; JENSEN J.S.; KOT W.P.; CASTRO-MEJIA J.L.; DENG L.; LESER T.D.;, NIELSEN D.S. (2020). Characterization of the Vaginal DNA Virome in Health and Dysbiosis. Viruses, v. 12, n. 10, p. 1143, 2020.
LEE, W. L.; LIU, C.H.; CHENG, M.; CHANG, W.H.; LIU, W. M.; WANG, P.H. Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision. International Journal of Molecular Science, v. 13, n. 22, 2021.
LIU, N. N.; ZHAO X.; TAN J.C.; LIU S.; LI B.W.; XU W.X.; PENG L.; GU P.; LI W.; SHAPIRO R.; ZHENG X.; ZHAO W.; JIANG Y.G.; CHEN D.; XU D.; WANG H. Mycobiome Dysbiosis in Women with Intrauterine Adhesions. Microbiology Spectrum, v. 10, n. 4, 2022.
MANDAR, R.; PUNAB, M.; BOROVKOVA, N.; LAPP, E.; KIIKER, R.; KORROVITS, P.; METSPALU, A.; KRJUTŠKOV, K.; NÕLVAK, H.; PREEM J. K.; OOPKAUP, K.; SALUMETS A.; TRUU, J. Complementary seminovaginal microbiome in couples. Research in Microbiology, v. 166, n. 5, p. 440-447, 2015.
ORGANIZACIÓN MUNDIAL DE LA SALUD. Infertilidad. OMS, 2019. Disponível em: https://www.who.int/health-topics/infertility#tab=tab_1. Acesso em: 1 de abr. 2023.
PUNZÓN-JIMÉNEZ, P.; LABARTA, E. The impact of the female genital tract microbiome in women health and reproduction: A review. Journal of Assisted Reproduction and Genetics, v. 38, n. 10, p. 2519-2541, 2021.
RAVEL, J.; MORENO, I.; SIMÓN, C. Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. American Journal of Obstetrics and Gynecology, v. 224, n. 3, p. 251-257, 2020.
RAVEL, J.; GAJER, P.; ABDO, Z.; SCHNEIDER, G. M.; KOENIG, S. K. K.; Stacey L MCCULLE, S. L.; KARLEBACH, S.; GORLE, R.; RUSSELL, J.; TACKET, C. O.; BROTMAN, R. M.; DAVIS, C. C.; AULT, K.; PERALTA, L.; FORNEY, L.J. Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences, v. 108, p. 4680–4687, 2010.
SARAF, V. S.; SHEIKH, S. A.; AHMAD, A.; GILLEVET, P. M.; BOKHARI, H.; JAVED, S. Vaginal microbiome: normalcy vs dysbiosis. Archives of microbiology, v. 203, p. 3793-3802, 2021.
SCHENK, M.; GRUMET L.; STERNAT J.; REINSCHISSLER N.; WEISS G. Effect of probiotics on vaginal Ureaplasma parvum in women suffering from unexplained infertility. Reproductive biomedicine online, v. 43, n. 3, p. 503-514, 2021.
SILVA, M. C. F. Reprodução Humana e Manipulação da Fertilidade. 2012. Tese de Doutorado. [Tese]. Universidade de Minho Escola de Ciência.
SILVA, S. M. B.; DUTRA, P. D. S. S.; SALES, A. I. L.; PADILHA , D. M. M.. Impact of the uterine microbiota on assisted reproduction: literature review. Research, Society and Development, [S. l.], v. 11, n. 16, 2022.
SRINIVASAN, S.; MORGAN M.T.; FIEDLER T. L.; DJUKOVIC D.; HOFFMAN N. G.; RAFTERY D.; MARRAZZO J. M.; FREDRICKS D. N. Metabolic signatures of bacterial vaginosis. MBio, v. 6, n. 2, 2015.
URSELL, L. K.; METCALF, J. L; PARFREY, L. W.; KNIGHT, R. Defining the human microbiome. Nutrition reviews, v. 70, n. suppl_1, p. 38-44, 2012.
USYK, M.; SCHLECHT, F.N.; PICKERING, S.; WILLIAMS, L.; SOLLECITO, C.C.; GRADISSIMO, A.; PORRAS, C.; SAFAEIAN, M.; PINTO, L.; HERRERO, R.; STRICKLER, H.D.; VISWANATHAN, S.; NUCCI-SACK, A.; DIAZ, A.; COSTA RICA HPV VACCINE TRIAL (CVT) GROUP; BURK, R.B. et al. molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history. Nature Communications, v. 13, n. 1, 2022.
VAN DE WIJGERT, J. H. H. M.; VERWIJS, M.C.; AGABA, S. K.; BRONOWSKI, C.; MWAMBARANGWE, L.; UWINEZA, M.; LIEVENS, E.; NIVOLIEZ, A.; RAVEL, J.; DARBY, A.C.. Intermittent Lactobacilli-containing Vaginal Probiotic or Metronidazole Use to Prevent Bacterial Vaginosis Recurrence: A Pilot Study Incorporating Microscopy and Sequencing. Scientific Reports, v. 10, 2020.
VENNERI, M. A.; FRANCESCHINI, E.; SCIARRA, F.; ROSATO, E.; D'ETTORRE, G.; LENZI, A. Human genital tracts microbiota: dysbiosis crucial for infertility. Journal of Endocrinological Investigation, v. 45, n. 6, p. 1151-1160, 2022.
VERSTRAELEN, H.; SWIDSINSKI, A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment: 2018 update. Current opinion in infectious diseases, v. 32, n. 1, p. 38-42, 2019.
VINTURACHE, A. E.; GYAMFI-BANNERMAN, C.; HWANG, J.; MYSOREKAR, I. U.; JACOBSSON, B.; PRETERM BIRTH INTERNATIONAL COLLABORATIVE (PREBIC). Maternal microbiome–a pathway to preterm birth. In: Seminars in Fetal and Neonatal Medicine, v. 21, n. 2, p. 94-99, 2016.
WEE B. A.; THOMAS M.; SWEENEY E. L.; FRENTIU F. D.; SAMIOS M.; RAVEL J.; GAJER P.; MYERS G.; TIMMS P.;, ALLAN J. A.; HUSTON W. M. A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women. The Australian & New Zealand journal of obstetrics & gynaecology, v. 58, n. 3, p. 341-348, 2018.
ZHANG F.; DAI, J.; CHEN, T. Role of Lactobacillus in Female Infertility Via Modulating Sperm Agglutination and Immobilization. Frontiers in cellular and infection microbiology, v. 10, 202.
