Effects of curcumin on cystic fibrosis: a systematic review

Efeitos da curcumina na fibrose cística: uma revisão sistemática

Autores

Izabela Zibetti de Albuquerque
Lusmaia Damaceno Camargo Costa
Patrícia Marques Fortes
Guilherme Matos Abe
Paulo Sérgio Sucasas da Costa

Resumo

The evidence that curcumin has restorative effects on the chlorine channels function is contradictory in the literature. This systematic review summarizes of molecular and clinical effects of curcumin related to cystic fibrosis (CF). Three databases were searched, where the outcome was the maturation, transport, expression and functionality of cystic fibrosis trasmennrane regulator (CFTR). Were included studies in vitro and in vivo that compared curcumin supplementation with other bioactive compounds or placebo. Of the 19 studies included, 18 were in vitro and 1 was a randomized clinical trial, with low-moderate risk of bias. Curcumin seems to be related to genetic mutations that lead to a defect in the opening of the chloride and sodium channel, allowing the repair of the functionality of this protein. The effect in inducing CFTR maturation and the expression of its function on the cell surface, are conflicting. The use of curcumin in CF patients is incipient and does not allow clinical inferences. PROSPERO CRD42021229294.

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