Influence of genetics variants of the IL6 gene on major depressive disorder: a review
Influência das variantes genéticas do gene IL6 no transtorno depressivo maior: uma revisão
Palavras-chave:
Interleukin-6, Polymorphism, Major Depressive DisorderResumo
The aim of this study was to elucidate the clinical picture of Major Depressive Disorder (MDD) with polymorphisms involving the IL6 gene. It was a systematic review with a search for original articles in the Scopus, Web of Science, PubMed, and BVS databases, which provided information on genetic variants related to IL6 gene polymorphisms. Studies that did not present complete data, including statistical data, were excluded. Fifty-four articles were found in the databases. The Rayyan platform was used to remove duplicates and read abstracts for initial selection. Twelve articles remained, and those that were freely accessible were selected for full reading, totaling 5 articles for this review. Evidence suggests a systemic condition in MDD, with data demonstrating inflammatory alterations. Given that in most studies, patients with MDD had higher inflammatory states, there appears to be a relationship between IL-6 and the disorder. IL-6 induces changes in the brain, activates microglia, and controls neuronal health, potentially making the relationship between polymorphisms and the disease tangible, but there are still few studies in the field.
Downloads
Referências
AMERICAN PSYCHIATRIC ASSOCIATION. Manual diagnóstico e estatístico de transtornos mentais: DSM-5 - 5a Edição. [s.l: s.n.]. v. 5° Edt
BECK, A. T.; ALFORD, B. A. Depressão causas e tratamento. [s.l: s.n.]. v. 2° Edição
BUFALINO, C. et al. The role of immune genes in the association between depression and inflammation: A review of recent clinical studies. Brain, Behavior, and Immunity, jul. 2013.
CARVALHO, S. et al. IL6-174G > C genetic polymorphism influences antidepressant treatment outcome. NORDIC JOURNAL OF PSYCHIATRY, v. 71, n. 2, p. 158–162, 2017.
DOSSUS, L. et al. PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: Results from the Breast and Prostate Cancer Cohort Consortium (BPC3). Carcinogenesis, v. 31, n. 3, p. 455–461, mar. 2010.
DRAGANOV, M. et al. Association study of polymorphisms within inflammatory genes and methylation status in treatment response in major depression. EUROPEAN PSYCHIATRY, v. 60, p. 7–13, 2019.
GONÇALVES, A. M. C. et al. Prevalence of depression and associated factors in women covered by family health strategy. Jornal Brasileiro de Psiquiatria, v. 67, n. 2, p. 101–109, 1 jan. 2018.
GRACE, L.; VILELA, L. Pós Graduação em Loto-Sensu em Especialização de Farmacologia (UFMG). 2015.
JANSEN, R. et al. Gene expression in major depressive disorder. Mol Psychiatry, v. 21, n. 3, p. 339–347, 2016.
KLAFKE, K. Determinação do papel das citocinas inflamatórias IL6 e IL8 na proliferação, resistência quimioterápica e invasão celular em glioblastoma humano. Universidade Federal do Rio Grande do Sul (UFRGS) Instituto de Ciências Básicas da Saúde, 2015.
LISOWAY, A. J. et al. DNA methylation and clinical response to antidepressant medication in major depressive disorder: A review and recommendations. Neuroscience LettersElsevier Ireland Ltd, 16 mar. 2018.
MARQUES, A. H.; CIZZA, G.; STERNBERG, E. Interações imunocerebrais e implicações nos transtornos psiquiátricos. Revista Brasileira de Psiquiatria, 2007.
MREJEN, M.; HONE, T.; ROCHA, R. Socioeconomic and racial/ethnic inequalities in depression prevalence and the treatment gap in Brazil: A decomposition analysis. SSM - Population Health, v. 20, 1 dez. 2022.
PARANHOS, M. E.; WERLANG, B. G. DIAGNÓSTICO E INTENSIDADE DA DEPRESSÃO. [s.l: s.n.].
PRESTES, J. et al. Papel Da Interleucina-6 Como Um Sinalizador Em Diferentes Tecidos Durante O Exercício Físico. Fitness & Performance Journal, v. 6, n. 5, p. 348–353, 2006.
ROBERTO NUNES GUEDES SECRETÁRIO ESPECIAL DE FAZENDA WALDERY RODRIGUES JUNIOR, P. et al. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA-IBGE. [s.l: s.n.].
SÁ, H. P.; SPANGHERO, M. S. Transtorno Depressivo Maior (TDM) com e sem Sintomas Psicóticos: Investigação Neuroquímica por Espectroscopia de Próton. Ribeirão Preto - SP: [s.n.].
UHER, R. et al. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry, v. 167, n. 5, p. 555–564, 2010.
ZHANG, C. et al. Identification of IL6 as a susceptibility gene for major depressive disorder. SCIENTIFIC REPORTS, v. 6, 2016.
