Clinical variables related to the ApoB polymorphism in patients undergoing bariatric surgery
Variáveis clínicas relacianadas com o polimorfismo do ApoB em pacientes submetidos a cirurgia bariátrica
Palavras-chave:
APOB, XBAI, RYGBResumo
The aim of this study was to assess whether biochemical, biological, and anthropometric characteristics are related to the XbaI polymorphism of APOB in obese patients aged 50+, as well as to verify susceptibility to health impairment. This research is a cross-sectional, comparative, analytical study with both quantitative and qualitative approaches, consisting of 21 elderly women aged 50 years or older who underwent Roux-en-Y- gastric bypass surgery one year ago. Clinical data and blood samples were collected 12 months after surgery, and genotyping was performed using the PCR-RFLP technique. The data indicated that there was no statistical association between the presence of the polymorphism and morbid obesity (P=0,302); however, it was found that the X+ alelle leads to reduced median of adipose mass in patients (P=0,031).
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Referências
ALVES, E. S. et al. The APOB rs693 polymorphism impacts the lipid profile of Brazilian older adults. Brazilian Journal of Medical and Biological Research, v. 53, n. 3, 2020.
BEHBODIKHAH, J. et al. Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target. Metabolites, v. 11, n. 10, p. 690, 8 out. 2021.
BOGARI, N. M. et al. No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects. Journal of Negative Results in BioMedicine, v. 14, n. 1, 18 mar. 2015.
DENG, X. et al. Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation. Lipids in Health and Disease, v. 20, n. 1, p. 123, 29 set. 2021.
GU, W.; ZHANG, M.; WEN, S. Association between the APOB XbaI and EcoRI polymorphisms and lipids in Chinese: A meta-analysis. Lipids in Health and Disease, v. 14, n. 1, 7 out. 2015.
IONUT, V.; BERGMAN, R. N. Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery. Journal of Diabetes Science and Technology, v. 5, n. 5, p. 1263–1282, 1 set. 2011.
KJELLMO, C. A. et al. Bariatric surgery improves lipoprotein profile in morbidly obese patients by reducing LDL cholesterol, apoB, and SAA/PON1 ratio, increasing HDL cholesterol, but has no effect on cholesterol efflux capacity. Journal of Clinical Lipidology, v. 12, n. 1, p. 193–202, jan. 2018.
NASI, A. Disfagia: definição, sintomas associados, causas e diagnóstico. Colégio Brasileiro de Cirurgia Bariátrica. Disponível em: < https://cbcd.org.br/biblioteca-para-o-publico/disfagia-definicao-sintomas-associados-causas-e-diagnostico/> . Acesso em 13/12/2023.
NASSIF, P. A. N. et al. WHEN AND WHY OPERATE ELDERLY OBESE. ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo), v. 28, n. suppl 1, p. 84–85, 2015.
NOR HANIPAH, Z. et al. The Outcome of Bariatric Surgery in Patients Aged 75 years and Older. Obesity Surgery, v. 28, n. 6, p. 1498–1503, 30 jun. 2018.
OLIVEIRA, M. ASSOCIAÇÃO DOS POLIMORFISMOS XbaI E EcoRI DO GENE DA APOLIPOPROTEÍNA B COM A DOENÇA ARTERIAL CORONARIANA E DIABETES MELLITUS TIPO 2. 2005.
PAJECKI, D. et al. Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass in the Elderly: 1-Year Preliminary Outcomes in a Randomized Trial (BASE Trial). Obesity Surgery, v. 31, n. 6, p. 2359–2363, 8 jun. 2021.
PAREJA, J. C.; GELONEZE, B. Operational mechanisms of anti-obesity surgeries. 2006. Disponível em: <https://www.researchgate.net/publication/26540324>.
RAMIREZ, A. et al. Outcomes of bariatric surgery in patients >70 years old. Surgery for Obesity and Related Diseases, v. 8, n. 4, p. 458–462, jul. 2012.
RENGES, H. et al. Genetic relationship between the 3‘‐VNTR and diallelic apolipoprotein B gene polymorphisms: Haplotype analysis in individuals of European and South Asian origin. Annals of Human Genetics, v. 56, n. 1, p. 11–33, 28 jan. 1992.
RUNGE, T. M. et al. Dysphagia predicts greater weight regain after Roux-en-Y gastric bypass: a longitudinal case-matched study. Surgery for Obesity and Related Diseases, v. 15, n. 12, p. 2045–2051, 1 dez. 2019.
SANTOS, E. EFEITO DA CIRURGIA BARIÁTRICA SOBRE OS NÍVEIS DE VITAMINA D DE PACIENTES OBESOS. 2020. Disponível em: <https://repositorio.ufpe.br/handle/123456789/38872>. Acesso em: 13/12/2023.
SCARTEZINI, M. et al. The X-X-/E+E+ genotype of the XbaI/EcoRI polymorphisms of the apolipoprotein B gene as a marker of coronary artery disease in a Brazilian sample. Brazilian Journal of Medical and Biological Research, v. 36, n. 3, p. 369–375, mar. 2003.
TURNER, P. DNA polymorphisms of the apoprotein B gene are associated with altered plasma lipoprotein concentrations but not with perceived risk of cardiovascular disease: European Atherosclerosis Research Study. Atherosclerosis, v. 116, n. 2, p. 221–234, ago. 1995.
WEBB, R. J. et al. The role of adiposity, diet and inflammation on the discordance between LDL-C and apolipoprotein B. Nutrition, Metabolism and Cardiovascular Diseases, v. 32, n. 3, p. 605–615, mar. 2022.
WORLD HEALTH ORGANIZATION. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization technical report series, v. 894, p. i–xii, 1–253, 2000.
WORLD HEALTH ORGANIZATION. Obesity and Overweight . Disponível em:< https://www.who.int/en/news-room/fact-sheets/detail/obesity-and-overweight>. Acesso em 14/12/2023.
ZHANG, L. et al. Association study between C7673T polymorphism in apolipoprotein B gene and cerebral infarction with family history in a Chinese population. Neurology India, v. 57, n. 5, p. 584, 2009.
