Risk factors for the development of candidemia in patients with positive urine surveillance culture for Candida spp.
Fatores de risco para o desenvolvimento de candidemia em pacientes com cultura de vigilância de urina positiva para Candida spp.
DOI:
https://doi.org/10.53660/CLM-3272-24G41Palavras-chave:
Candida spp. infection, Candidemia, Risk Factors, Intensive Care UnitResumo
The objective of the study was to characterize candiduria in patients admitted to a tertiary hospital and establish the risk factors associated with the development of candidemia. To this end, a laboratory and clinical surveillance study was carried out with samples of Candida spp. previously isolated from urine surveillance cultures of patients admitted to the Intensive Care Unit, during the period from 2019 to 2020. It was demonstrated that the incidence of candidemia in patients with positive urine cultures for Candida spp. it was 17.7 per 1000 admissions and 80% of patients who developed candidemia died. The chance of developing candidemia was eight times greater in patients who had diseases of the digestive system that caused hospitalization and 26 times greater in those who had Coronary Artery Disease (CAD), compared to patients who did not have the comorbidity. We concluded that the possibility of developing candidemia from candiduria is 4.5%, however, the onset of candidemia, regardless of the source, worsens the patient's prognosis.
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Referências
CAROLIS, E. DE et al. BIOF–HILO assay: A new MALDI–TOF mass spectrometry based method for discriminating between high-and low-biofilm-producing Candida parapsilosis isolates. Frontiers in Microbiology, v. 10, n. AUG, 2019.
CHU, H. et al. The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease. Journal of Hepatology, v. 72, n. 3, 2020.
COLOMBO, A. L.; GUIMARÃES, T. Candidúria: uma abordagem clínica e terapêutica. Revista da Sociedade Brasileira de Medicina Tropical, v. 40, n. 3, 2007.
DA ROCHA, W. R. V. et al. Gênero Candida - Fatores de virulência, epidemiologia, candidíase e mecanismos de resistência. Research, Society and Development, v. 10, n. 4, 2021.
DROGARI-APIRANTHITOU, M. et al. Association Between Candiduria and candidemia: A clinical and molecular analysis of cases. Mycopathologia, v. 182, n. 11–12, 2017.
GIOLO, M. P.; SVIDZINSKI, T. I. E. Fisiopatogenia, epidemiologia e diagnóstico laboratorial da candidemia. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 46, n. 3, 2010.
KAUFFMAN, C. A. et al. Candida urinary tract infections - Diagnosis. Clinical Infectious Diseases, v. 52, n. SUPPL. 6, 2011.
LANG, S. et al. Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis. Hepatology, v. 71, n. 2, 2020.
LORTHOLARY, O. et al. Worrisome trends in incidence and mortality of candidemia in intensive care units (Paris area, 2002-2010). Intensive Care Medicine, v. 40, n. 9, 2014.
MCCARTY, T. P.; PAPPAS, P. G. Invasive Candidiasis. Infectious Disease Clinics of North America, v. 30, n. 1, 2016.
PAPPAS, P. G. et al. Invasive candidiasis. Nature Reviews Disease Primers, v. 4, 2018.
RAMOS, L. S. et al. Biofilm formed by Candida haemulonii species complex: Structural analysis and extracellular matrix composition. Journal of Fungi, v. 6, n. 2, 2020.
SANTOS, E. R. DOS. Avaliação da suscetibilidade de Candida spp. isoladas de candidemias: um estudo de 15 anos. Dissertação (Mestrado em Farmacologia): Universidade Federal de Santa Maria, 2012.
SILVA, A. K. F. DA et al. Infecções urinárias nosocomiais causada por fungo do gênero Candida: uma revisão. Caderno de Graduação - Ciências Biológicas e da Saúde, v. 2, n. 1, 2014.
SILVEIRA, A. C. R. Infecções fúngicas em unidade de terapia intensiva cardiológica e caracterização dos agentes etiológicos quanto à capacidade de aderência e formação de biofilme. Dissertação (Mestrado em Biologia de Fungos): Universidade Federal de Pernambuco, 2013.
SINGH, D. P. et al. Non-Candida albicans Candida species: Virulence factors and species identification in India. Current Medical Mycology, v. 7, n. 2, 2021.
SOBEL, J. D. et al. Candida urinary tract infections - Epidemiology. Clinical Infectious Diseases, v. 52, n. SUPPL. 6, 2011.
