The use of mesenchymal stem cells in tendon regeneration in rats.
O uso de células-tronco mesenquimais na regeneração do tendão em ratos.
Palavras-chave:
Célula-tronco mesenquimal, Lesão tendínea, Regeneração, TenogêneseResumo
Mesenchymal stem cells are of great interest due to their regenerative potential and capacity to transdifferentiate into various cell lineages. The present study executed a narrative review of the literature on the influence of mesenchymal stem cells on the regeneration of tendon injuries. To acomplish this, a search was carried out in the Pubmed and Scielo databases using descriptors such as: Mesenchymal stem cell regeneration and application tendon rat; Embryonic Stem Cell-Derived Mesenchymal Stem Cells for Tendon Tissue rat. Only research articles carried out on rats between 2011 and 2023 were included. 935 articles were found in the Pubmed database, and 43 articles were included based on the criteria of categorization, analysis of titles and abstracts. The articles showed benefits in relation to the use of stem cells in rat tendon injuries, but some studies showed that this repair was not 100% guaranteed to the state of the tendon originally, but associated with growth factors obtained a better induction of tenogenesis.
Downloads
Referências
Aktas, E. et al. Immune modulation with primed mesenchymal stem cells delivered via biodegradable scaffold to repair an Achilles tendon segmental defect. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, v. 35, n. 2, p. 269–280, 2016.
Andarawis-Puri, N.; Flatow, E. L.; Soslowsky, L. J. Tendon basic science: Development, repair, regeneration, and healing. Journal of orthopaedic research: official publication of the Orthopaedic Research Society, v. 33, n. 6, p. 780–784, 2015.
Chen, Y., Shao, J.-Z., Xiang, L.-X., Dong, X.-J., & Zhang, G.-R. (2008). Mesenchymal stem cells: a promising candidate in regenerative medicine. The International Journal of Biochemistry & Cell Biology, 40(5), 815–820. https://doi.org/10.1016/j.biocel.2008.01.007.
Gissi, C. et al. Extracellular vesicles from rat-bone-marrow mesenchymal stromal/stem cells improve tendon repair in rat Achilles tendon injury model in dose-dependent manner: A pilot study. PloS one, v. 15, n. 3, p. e0229914, 2020.
Jiang, D. et al. Combined effects of engineered tendon matrix and GDF-6 on bone marrow mesenchymal stem cell-based tendon regeneration. Biotechnology letters, v. 38, n. 5, p. 885–892, 2016.
Kang, K. et al. Upregulation of Runt related transcription factor 1 (RUNX1) contributes to tendon–bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells. Journal of orthopaedic surgery and research, v. 17, n. 1, 2022.
Kraus, T. M. et al. Stem cells and basic fibroblast growth factor failed to improve tendon healing: An in vivo study using Lentiviral gene transfer in a rat model. The Journal of bone and joint surgery. American volume, v. 96, n. 9, p. 761–769, 2014.
Lee, J. Y. et al. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PloS one, v. 6, n. 3, p. e17531, 2011.
Lui, P. P. Y.; Wong, O. T. Tendon stem cells: experimental and clinical perspectives in tendon and tendon-bone junction repair. Muscles, ligaments and tendons journal, v. 2, n. 3, p. 163–168, 2012.
Urdzikova, L., Sedlacek, R., Suchy, T. et al. Human multipotent mesenchymal stem cells improve healing after collagenase tendon injury in the rat. BioMed Eng OnLine 13, 42 (2014).
Monteiro, B. S.; ARGOLO NETO, N. M.; DEL CARLO, R. J. Células-tronco mesenquimais. Ciencia rural, v. 40, n. 1, p. 238–245, 2010.
Oliva, F. et al. Combined ascorbic acid and T3 produce better healing compared to bone marrow mesenchymal stem cells in an Achilles tendon injury rat model: a proof of concept study. Journal of orthopaedic surgery and research, v. 14, n. 1, 2019.
Pietschmann, M. F. et al. Comparison of tenocytes and mesenchymal stem cells seeded on biodegradable scaffolds in a full-size tendon defect model. Journal of materials science. Materials in medicine, v. 24, n. 1, p. 211–220, 2013.
Rui, Y. F. et al. Higher BMP receptor expression and BMP-2-induced osteogenic differentiation in tendon-derived stem cells compared with bone-marrow-derived mesenchymal stem cells. International orthopaedics, v. 36, n. 5, p. 1099–1107, 2012.
Selek, O. Mesenchymal stem cell application improves tendon healing via anti-apoptotic effect (Animal study). Acta orthopaedica et traumatologica turcica, v. 48, n. 2, p. 187–195, 2014.
Veronesi, F. et al. Mesenchymal stem cells for tendon healing: what is on the horizon?: Mesenchymal stem cells in acute and chronic tendon injuries. Journal of tissue engineering and regenerative medicine, v. 11, n. 11, p. 3202–3219, 2017.
Wang, J. et al. Characterization and therapeutic applications of mesenchymal stem cells for regenerative medicine. Tissue & cell, v. 64, n. 101330, p. 101330, 2020.
Yin, Z. et al. Stepwise differentiation of mesenchymal stem cells augments tendon-like tissue formation and defect repair in vivo. Stem cells translational medicine, v. 5, n. 8, p. 1106–1116, 2016.
Zhang, B. et al. Construction of tendon replacement tissue based on collagen sponge and mesenchymal stem cells by coupled mechano-chemical induction and evaluation of its tendon repair abilities. Acta biomaterialia, v. 74, p. 247–259, 2018.
