Descriptive study of patients with COVID-19 referred to the ICU and outcome in field hospitals in the Federal District during the Pandemic.
Estudo descritivo dos pacientes com COVID-19 encaminhados à UTI e desfecho em hospitais de campanhas do Distrito Federal durante a Pandemia.
Palavras-chave:
COVID-19, Field Hospitals, ICU Intensive Care Units, Severe Acute RespiratoryResumo
Introduction: The COVID-19 pandemic presented unprecedented challenges due to the number of patients who developed acute respiratory failure The Field Hospital is mainly characterized as a hospital structure, put into use quickly, of a temporary nature, intended to care for patients with similar medical conditions, characterized as a consequence of pandemics or catastrophes of natural or human causes. In this sense, this study aims to describe the profile and clinical outcomes of patients with COVID-19 admitted to field hospitals in the Federal District during the Covid-19 Pandemic.Methodology: Descriptive, documentary study of all patients admitted to ICUs in four field hospitals in the Federal District, Brazil. There were 1584 patients hospitalized in Field Hospitals Results: There were 894 (56.4%) males, median age of 61 years, 31.4% were overweight and 37.1% were obese. Length of stay with a median of 12 days.The mortality rate was 63.6%.Conclusion: The patients referred were older, male, the majority without reported comorbidities, the majority already had insufficiency hemodynamics, sepsis or septic shock, and respiratory failure upon admission.
Downloads
Referências
ALHAZZANI W, EVANS L, ALSHAMSI F ET AL. Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update. Crit Care Med. 2021 Mar 1;49(3):e219-e234.
BHATRAJU PK, GHASSEMIEH BJ, NICHOLS M, KIM R, JEROME KR, NALLA AK, GRENINGER AL, PIPAVATH S, WURFEL MM, EVANS L, KRITEK PA, WEST TE, LUKS A, GERBINO A, DALE CR, GOLDMAN JD, O'MAHONY S, MIKACENIC C. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series. N Engl J Med. 2020 May 21;382(21):2012-2022. doi: 10.1056/NEJMoa2004500. Epub 2020 Mar 30. PMID: 32227758; PMCID: PMC7143164.
BRASIL, Ministério da Saúde. Painel Coronavírus [Internet]. Brasília(DF);2021.Avialable from:https//covid.saude.gov.br/
CDC COVID-19 RESPONSE TEAM, CDC COVID-19 RESPONSE TEAM, CDC COVID-19 RESPONSE TEAM, BIALEK, S., BOUNDY, E., BOWEN, V., ... & SAUBER-SCHATZ, E. (2020). Severe outcomes among patients with coronavirus disease 2019 (COVID-19)—United States, February 12–March 16, 2020. Morbidity and mortality weekly report, 69(12), 343-346.
CHARLSON ME, POMPEI P, ALES KL, MACKENZIE CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83
CORRÊA, T. D., MIDEGA, T. D., TIMENETSKY, K. T., CORDIOLI, R. L., BARBAS, C. S. V., SILVA JÚNIOR, M., BRAVIM, B. DE A., SILVA, B. C., MATOS, G. F. J. DE ., NAWA, R. K., CARVALHO, F. R. T. DE ., QUEIROZ, V. N. F., RABELLO FILHO, R., PIZA, F. M. DE T., PEREIRA, A. J., PESAVENTO, M. L., EID, R. A. C., SANTOS, B. F. C. DOS ., PARDINI, A., … FERRAZ, L. J. R.. (2021). Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study. Einstein (são Paulo), 19, eAO6739.
COVIDSurg Collaborative. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study. Lancet Oncol. 2021 Nov;22(11):1507-1517. doi: 10.1016/S1470-2045(21)00493-9. Epub 2021 Oct 5. PMID: 34624250; PMCID: PMC8492020.
DAVID A KASS, PRIYA DUGGAL, OSCAR CINGOLANI. Obesity could shift severe COVID-19 disease to younger ages. The Lancet,Volume 395, Issue 10236, 2020, Pages 1544-1545. ISSN 0140-6736. https://doi.org/10.1016/S0140-6736(20)31024-2.
DE MORAES, DIOGO ET AL. Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19. Aging and disease, v. 12, n. 1, p. 42, 2021
FREITAS, A. R. R., NAPIMOGA, M., & DONALISIO, M. R.. (2020). Análise da gravidade da pandemia de Covid-19. Epidemiologia E Serviços De Saúde, 29(2), e2020119. https://doi.org/10.5123/S1679-49742020000200008
HUANG Y, LU Y, HUANG YM, WANG M, LING W, SUI Y, ZHAO HL. Obesity in patients with COVID-19: a systematic review and meta-analysis. Metabolism. 2020 Dec;113:154378. doi: 10.1016/j.metabol.2020.154378. Epub 2020 Sep 28. PMID: 33002478; PMCID: PMC7521361.
HUANG, D., LIAN, X., SONG, F., MA, H., LIAN, Z., LIANG, Y., QIN, T., CHEN, W., & WANG, S. (2020). Clinical features of severe patients infected with 2019 novel coronavirus: a systematic review and meta-analysis. Annals of translational medicine, 8(9), 576.
HU, B., GUO, H., ZHOU, P., & SHI, Z. L. (2021). Characteristics of SARS-CoV-2 and COVID-19. Nature reviews. Microbiology, 19(3), 141–154.
KIRTIPAL, N., BHARADWAJ, S., & KANG, S. G. (2020). From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases, 85, 104502.
LI, X., XU, S., YU, M., WANG, K., TAO, Y., ZHOU, Y., SHI, J., ZHOU, M., WU, B., YANG, Z., ZHANG, C., YUE, J., ZHANG, Z., RENZ, H., LIU, X., XIE, J., XIE, M., & ZHAO, J. (2020). Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. The Journal of allergy and clinical immunology, 146(1)
LUZI, L., RADAELLI, M.G. Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic. Acta Diabetol 57, 759–764 (2020). https://doi.org/10.1007/s00592-020-01522-8
NICHOLLS, J., DONG, X. P., JIANG, G., & PEIRIS, M. (2003). SARS: clinical virology and pathogenesis. Respirology (Carlton, Vic.), 8 Suppl(Suppl 1), S6–S8. https://doi.org/10.1046/j.1440-1843.2003.00517.x
MOREIRA, R. DA S. (2020). COVID-19: unidades de terapia intensiva, ventiladores mecânicos e perfis latentes de mortalidade associados à letalidade no Brasil. Cadernos De Saúde Pública, 36(5), e00080020.
MORENO RP, METNITZ PG, ALMEIDA E, JORDAN B, BAUER P, CAMPOS RA, IAPICHINO G, EDBROOKE D, CAPUZZO M, LE GALL JR; SAPS 3 Investigators. SAPS 3-From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission. Intensive Care Med. 2005;31(10):1345-55. Erratum in: Intensive Care Med. 2006;32(5):796
NADIM MK, FORNI LG, MEHTA RL, CONNOR MJ JR, LIU KD, OSTERMANN M, RIMMELÉ T, ZARBOCK A, BELL S, BIHORAC A, CANTALUPPI V, HOSTE E, HUSAIN-SYED F, GERMAIN MJ, GOLDSTEIN SL, GUPTA S, JOANNIDIS M, KASHANI K, KOYNER JL, LEGRAND M, LUMLERTGUL N, MOHAN S, PANNU N, PENG Z, PEREZ-FERNANDEZ XL, PICKKERS P, PROWLE J, REIS T, SRISAWAT N, TOLWANI A, VIJAYAN A, VILLA G, YANG L, RONCO C, KELLUM JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nat Rev Nephrol. 2020 Dec;16(12):747-764. doi: 10.1038/s41581-020-00356-5. Epub 2020 Oct 15. Erratum in: Nat Rev Nephrol. 2020 Nov 2;: PMID: 33060844; PMCID: PMC7561246.
POPKIN BM, DU S, GREEN WD, BECK MA, ALGAITH T, HERBST CH, ALSUKAIT RF, ALLUHIDAN M, ALAZEMI N, SHEKAR M. Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obes Rev. 2020 Nov;21(11):e13128. doi: 10.1111/obr.13128. Epub 2020 Aug 26. Erratum in: Obes Rev. 2021 Oct;22(10):e13305. PMID: 32845580; PMCID: PMC7461480.
ROBERT P. RUNNER, JAIME L. BELLAMY, CATPHUONG CATHY L. VU, GREG A. ERENS, MARA L. SCHENKER, GEORGE N. GUILD,(2017). Modified Frailty Index Is an Effective Risk Assessment Tool in Primary Total Knee Arthroplasty,The Journal of Arthroplasty,Volume 32, Issue 9, Supplement,2017.
SOARES M, BOZZA FA, ANGUS DC, JAPIASSÚ AM, VIANA WN, COSTA R, ET AL. Organizational characteristics, outcomes, and resource use in 78 Brazilian intensive care units: the ORCHESTRA study. Intensive Care Med. 2015;41(12):2149-60.
VELANOVICH V, ANTOINE H, SWARTZ A, PETERS D, RUBINFELD I. Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. J Surg Res. 2013;183(1):104-10
VINCENT JL, MORENO R, TAKALA J, WILLATTS S, DE MENDONCA A, BRUINING H, ET AL. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22(7):707-10.
YANG HJ, ZHANG YM, YANG M, HUANG X. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2. Eur Respir J. 2020 Sep 24;56(3):2002439. doi: 10.1183/13993003.02439-2020. PMID: 32747392; PMCID: PMC7397946.
ZAMPIERI, F. G., & COLOMBARI, F. (2015). Modelo de análise gradiente boosted do impacto do índice de massa corporal nos desfechos em curto prazo de pacientes clínicos gravemente enfermos. Revista Brasileira De Terapia Intensiva, 27(2),
ZHOU W, QIN X, HU X, LU Y, PAN J. Prognosis models for severe and critical COVID-19 based on the Charlson and Elixhauser comorbidity indices. Int J Med Sci. 2020 Aug 25;17(15):2257-2263. doi: 10.7150/ijms.50007. PMID: 32922189; PMCID: PMC7484649.