Evaluation of the antimicrobial andantifungal activity of selenium, ketoprofen, ascorbic acid and their combinations
Avaliação da atividade antimicrobiana e antifúngica de selênio, cetoprofeno, ácido ascórbico e suas combinações
Palavras-chave:
Assessment, Microorganisms, SeleniumResumo
The purpose of this article is to evaluate whether there is and what is the antimicrobial activity and antifungal activity of three proposed substances and their combinations. Selenium, a substance widely used and studied as an antioxidant; ketoprofen, a non-steroidal anti-inflammatory drug widely used for various cases of inflammation; and ascorbic acid, also known as vitamin C, used as a necessary molecule in various biochemical processes in the human body. This work aims to carry out an in vitro antimicrobial activity test and evaluate the antifungal activity of selenium and ascorbic acid (vitamin C), compared to the effects caused by ketoprofen. It was observed that the combination of ketoprofen and selenium has little antimicrobial action. However, when we consider the two compounds in isolation, just ketoprofen or just selenium, we have the presence of antimicrobial action by both. And this discrepancy is even greater when there is an association between ketoprofen and ascorbic acid, the antimicrobial activity has been shown to be almost non-existent. In the antifungal test, it was observed that all compounds in all dilutions exhibited antifungal activity against the species tested.
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BARREIROS, L. B. S.; DAVID, J. M.; DAVID, J. P. Estresse oxidativo: relação entre geração de espécies reativas e defesas do organismo. Química Nova, São Paulo, v. 29, n.1, p. 113-123, 2006.
BIANCHI, M. L. P.; ANTUNES, L. M. G. Radicais Livres e os principais antioxidantes da dieta. Revista de Nutrição, Campinas, v. 12, n. 2, 123-130, 1999.
CHEN B, GILBERT LA, CIMINI BA, et al.: Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell. 2013;155(7):1479–91.
COS, P.; CALOMME, M.; SINDAMBIWE, J.B.; BRUYNE, DE T.; CIMANGA, K.; PIETERS, L.; VLIETINCK, A.J.; BERGHE, D.V. Cytotoxycity and lipid peroxidation-inhibiting activity of flavonoids. Planta Medica, New York, v. 67, p. 515-519, 2001
COSTA, D.; MOUTINHO, L.; LIMA, J.L.F.C.; FERNANDES, E. Antioxidant Activity and Inhibition of Human Neutrophil Oxidative Burst Mediated by Arylpropionic Acid Non-steroidal Antiinflammatory Drugs. Biol. Pharm. Bull. 29 (8) (2006) 1659 – 1670.
DE FRANCESCO EM, BONUCCELLI G, MAGGIOLINI M, SOTGIA F, LISANTI MP. Vitamin C and doxycycline: a synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs). Oncotarget, 2017;8: 67269-67286.
HALLIWELL, B., GUTTERIDGE, J. M. C. 1999. Oxidative stress and antioxidant protection: some special cases. In: Halliwell, B.; Gutteridge, J. M. C. editors. Free Radicals in Biology and Medicine. 3 ed. Oxford: Clarendon Press, p. 530- 533.
HALLIWELL, B.; GUTTERIDGE, J. M. C. 2000. Free radicals in biology and medicine. 3 ed. Oxford: Clarendon, p. 936.
HE, Y.; RAMIREZ, D.C.; DETWEILER, C.D.; MASON, R.P.; CHIGNELL, C.F. UVA-ketoprofen– induced Hemoglobin Radicals Detected by Immuno–spin Trapping, Photochemistry and Photobiology 77(6) (2003) 585–591.
HÖFS S, MOGAVERO S, HUBE B. Interaction of Candida albicans with host cells: virulence factors, host defense, escape strategies, and the microbiota. J Microbiol. 2016 Mar;54(3):149-69.
JANSEN, S.JK. Oxidative stress and free radicals. Journal of Molecular Structure (Theochem), Amesterdan, v. 666, n. 1/2, p. 387-392, 2003.
KANTOR, T. G. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy, 1986; v. 6, p. 93-103.
KANTOR, T.G. Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy. May-Jun;6(3) (1986) 93-103.
KAZEMI, M; JARRETT, B.Y; VANDEN, B. H; LIN, A.W; HOEGER, K.M; SPANDORFER, S.D; LUJAN, M. E. Obesity, Insulin Resistance, and Hyperandrogenism Mediate the Link between Poor Diet. Quality and Ovarian Dysmorphology in Reproductive Aged Women, Nutrients, 30;12(7):1953, 2020.
KIMURA, M.; TAKAI, M.; ISHIHARA, K. Biocompatibility and drug release behavior of spontaneously formed phospholipid polymer hydrogels. J.Biomed Mater Res A. Jan;80(1) (2007) 45-54.
KOJOURI, GHOLAMALI, ARBABI, FATEMEH, MOHEBBI, ABDOLNASER, 2020. The effects of selenium nanoparticles (SeNPs) on oxidant and antioxidant activities and neonatal lamb weight gain pattern. Comp. Clin. Path. 29 (2), 369–374.
NAKAJIMA, A.; TAHARA, M.; YOSHIMURA, Y.; NAKAZAWA, H. Determination of free radicals generated from light exposed ketoprofen. Journal of Photochemistry and Photobiology A: Chemistry 174 (2005) 89–97
NOBLE SM, GIANETTI BA, WITCHLEY JN. Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol. 2017 Feb;15(2):96-108. doi: 10.1038/nrmicro.2016.157. Epub 2016 Nov 21.
RAZA, A., PARVEEN, S., MAJEED, M. I., NAWAZ, H., JAVED, M. R., IQBAL, M. A., RASHID, N., HAIDER, M. Z., ALI, M. Z., SABIR, A., MAHMOOD Ul HASAN, H., & MAJEED, B. Surface-enhanced Raman spectral characterization of antifungal activity of selenium and zinc based organometallic compounds. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 285, 2023.
RODRIGUES, H. G.; DINIZ, Y. S.; FAINE, L. A; ALMEIDA, J. A.; FERNANDES, A. A. H.; NOVELLI, E. L. L. B. Suplementação nutricional com antioxidantes naturais: efeito da rutina na concentração de colestrol-HDL. Revista de Nutrição, Campinas, v. 16, n. 3, p. 315-320, 2003.
SHRIVASH MK, MISHRA S, PANWAR SL, SIRCAIK S, PANDEY J, MISRA K. Attenuation of pathogenicity in Candida albicans by application of polyphenols. J. Microb Biochem Technol. 2018; 10:27–39.
SIQUEIRA, F. M.; OETTERER, M.; REGINATO-D`ARCE, M. B. Nutrientes antioxidantes. Boletim SBCTA, Campinas, v. 31, n. 2, p. 192-199, 1997.
SIQUEIRA, F. M.; OETTERER, M.; REGINATO-D'ARCE, M. B. Nutrientes antioxidantes. Boletim SBCTA, Campinas, v. 31, n. 2, p. 192-199, 1997.
SOARES, S. E. Ácidos fenólicos como antioxidantes. Revista de Nutrição, Campinas, v. 15, n. 1, p. 71-81, 2002.
SUDBERY P, GOW N, BERMAN J. The distinct morphogenic states of Candida albicans. Trends Microbiol. 2004 Jul;12(7):317-24.
SUN, L., YE, X., DING, D., & KAI, L. Opposite effects of vitamin C and vitamin E on the antifungal activity of honokiol. Journal of microbiology and biotechnology, 2019;29(4), 538–547.
VÁSQUEZ-VIVAR, J; WHITSETT, J; MARTÁSEK, P.; HOGG, N; KALYANARARAMAN, B. Reation of tetrahidrobioterin with superoxide: EPR132
W. AHMAD, D. KALRA, Green synthesis, characterization and antimicrobial activit of ZnO nanoparticles using Euphorbia hirta leaf extract, J King Saud Univ. - Sci. 32 (4) (2020).
YU, B. P. Cellular defenses against damage from reactive oxygen species. Physiological Reviews, Washington DC, v. 74, p. 139-161, 1994.
