No effect of a low dose of omega-3 on the lipid profile of pregnant women with obesity: a randomized trial
Nenhum efeito de uma dose baixa de ômega-3 no perfil lipídico de gestantes obesas: um ensaio clínico randomizado
Palavras-chave:
Pregnancy, Triglycerides, Omega-3, Obesity, GlucoseResumo
Objective: Evaluate the lipid profile, fasting blood glucose, Body Mass Index (BMI) and weight gain of pregnant women with obesity and the effect of a low dose (1,1 g/day) of omega-3 on these parameters. Methods: A randomized clinical trial was performed from May 1st, 2019 to October 31th, 2022 with pregnant women diagnosed with obesity by arrival BMI ≥ 30.0 kg/m2. The participants were randomized into two groups: omega-3 and control. All pregnant women received standard prenatal follow-up and the same diet and physical exercise instructions. Laboratory tests were performed at three different times: first moment with gestational age (GA 12-20 weeks), second (GA 24-28 weeks) and third (GA 32-34 weeks) measuring maternal serum levels of glucose, total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides (TG) as well as weight gain and BMI were monitored. Results: A total of 172 pregnant women with obesity were evaluated. Of these, 87 (50.6%) composed the control group and 85 (49.4%) the omega-3 group. There was no difference of lipid profile, fasting blood glucose, BMI and weight gain values between groups during the 1st, 2nd and 3rd evaluation moments. Conclusion: Low dose (1,1 g/day) of omega-3 showed no effect on the lipid profile, fasting blood glucose, BMI and weight gain in pregnant women with obesity in omega-3 group during the evaluation moments.
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