miRNAs activate mitochondrial energy metabolism: a narrative view
miRNAs ativam o metabolismo energético mitocondrial: uma visão narrativa
Palavras-chave:
Mitochondria, miRNAs, MitomiR, ATPResumo
MicroRNAs (miRNAs) are small, non-coding single-stranded RNA molecules that participate in the repression of translation or degradation of messenger RNA. miRNAs play a significant role in cellular regulatory mechanisms and have been implicated in numerous pathological processes. However, research indicates the presence of miRNAs in mitochondria called mitomiRs originating from mitochondrial DNA, with direct action on genes encoding proteins and enzymes that participate in mitochondrial function. The mitochondrial localization of miRNAs has gained relevance since it was observed that mitomiR populations are modified throughout the cell cycle. Currently, miRNAs are known to act in several biological processes, including being considered key to better understand several processes that lead to ATP production as well as mitochondrial dysfunctions. Thus, the objective of this review is to narrate the molecular mechanisms of miRNAs actions in mitochondrial energy pathway.
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