Complications of Tenecteplase in pre-hospital care for treatment of acute myocardial infarction

Complicações do uso pré-hospitalar da Tenecteplase para tratamento do Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST

Autores

Palavras-chave:

ST-segment Elevation Myocardial Infarction, Tenecteplase, Pre-Hospital Care, Fibrinolytic, Emergency Medical Services

Resumo

The main objective of STEMI treatment is myocardial reperfusion, although FT is a viable and efficient option, it has possible complications like any other medication. The objective of this article to analyze the complications of the pre-hospital use of Tenecteplase for the treatment of Acute Myocardial Infarction. Was performed a study cross-sectional study, carried out in the Mobile Emergency Care Services and Emergency Care Units, with data analyzed by descriptive and inferential statistics. Fifty-three (53) medical records of patients with acute myocardial infarction who used Tenecteplase were analyzed. The use of the medication within 3 hours after the onset of symptoms decreased mortality and provided clinical improvement. Outcomes without clinical improvement were associated with time to onset of use greater than 3 hours. Tenecteplase was an effective therapy when administered within the first 3 hours from the onset of symptoms. However, it was evidenced that hemorrhagic risks are possible, but depended on the dose of fibrinolytic administered, the pharmacological therapy used and the clinical condition of the population studied.

Downloads

Não há dados estatísticos.

Referências

ARMSTRONG, P. W. et al. STREAM Investigative Team. Fibrinolysis or primary PCI in ST-segment elevation myocardial infarction. New England Journal of Medicine, v. 368, n. 15, p.1379-1387, 2013. doi: https://doi.org/10.1056/NEJMoa1301092

BAGAI, A. et al. Reperfusion Strategies in Acute Coronary Syndromes. Circulation, v. 114, n. 12, p.1918-28, 2014. doi: https://doi.org/10.1161/CIRCRESAHA.114.302744

BARUZZI, A. C. A.; STEFANINI, E.; MANZO, G. Fibrinolíticos: indicações e tratamento das complicações hemorrágicas. Revista da Sociedade de Cardiologia do Estado de São Paulo, v. 28, n. 4, p.421-427, 2018. doi: http://dx.doi.org/10.29381/0103-8559/20182804421-7

BONNEFOY, E. et al. Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study. The Lancet, v. 360, n. 1, p.825-829, 2002. doi: https://doi.org/10.1016/S0140-6736(02)09963-4

BUNDHUN, P. K.; JANOO, G.; CHEN, M. Bleeding events associated with fibrinolytic therapy and primary percutaneous coronary intervention in patients with STEMI: a systematic review and meta-analysis of randomized controlled trials. Medicine, v. 95, n. 23, p.1-9, jun. 2016. doi: https://doi.org/10.1097/MD.000000000003877

CÂMARA, P. F. M. et al. Desfechos clínicos de pacientes após uso de terapia fibrinolítica pré-hospitalar: revisão sistemática. Acta Paulista de Enfermagem, v. 33, p.1-9, 2020. doi: https://doi.org/10.37689/acta-ape/2020AR00946

COLLET, J. P. et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal, v. 42, n. 14, p.1289–1367, 2021. doi: https://doi.org/10.1093/eurheartj/ehaa575

DALAL, J. et al. Role of thrombolysis in reperfusion therapy for management of AMI: Indian scenario. Indian Heart Journal, v. 65, n. 5, p.566-585, 2013. doi: https://doi.org/10.1016/j.ihj.2013.08.032

DATASUS: Informações de Saúde, Morbidade e Informações Epidemiológicas [Internet]. Brasília: Ministério da Saúde Brasil. 2019.

GBD 2017 Causes of Death Collaborators: "Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017". The Lancet. 2018; 392: 1736-88. doi: https://doi.org/10.1016/S0140-6736(18)32203-7

GBD 2017. Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, v. 392, p. 1736-88, 2018. doi: https://doi.org/10.1016/S0140-6736(18)32203-7

GBD 2017. DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, v. 392, p. 1859-22, 2018. doi: https://doi.org/10.1016/S0140-6736(18)32335-3

GERSHLICK, A. H. et al. Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction. New England Journal of Medicine, v. 353, n. 26, p.2758-2768, dez. 2005. doi: https://doi.org/10.1056/NEJMoa050849

GIBSON, C. M. Time is myocardium and time is outcomes. Circulation, v. 104, n. 22, p.2632-4, nov. 2001. doi: https://doi.org/10.1161/hc4701.099731

GOMES JÚNIOR, M. P. M. et al. Vascular Complications in Patients Undergoing Early Percutaneous Coronary Intervention via the Femoral Artery after Fibrinolysis with Tenecteplase: Registry of 199 Patients. Revista Brasileira de Cardiologia Invasiva, v. 20, n. 3, p. 274–81, 2012. doi: http://dx.doi.org/10.1016/S2214-1235(15)30065-X

HENRY, T. D. et al. Invasive Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock: A Scientific Statement From the American Heart Association. Circulation, v. 143, n. 15, p.815-829, 2021. doi: https://doi.org/10.1161/CIR.0000000000000959

HUBER, K. et al. Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction. European Heart Journal, v. 26, n. 19, p.2063-2074, 2005. doi: https://doi.org/10.1093/eurheartj/ehi413

IBANEZ, B. et al. 2017 ESC Guidelines for the management of acute myo-cardial infarction in patients presenting with ST-segment elevation. The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal, v. 39, ed. 2, p.119-77, 2018. doi: https://doi.org/10.1093/eurheartj/ehx393

KNUUTI, J. et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). European Heart Journal, v. 41, n. 3, p. 407–477, 2020. doi: https://doi.org/10.1093/eurheartj/ehz425

KUNADIAN, V.; GIBSON, C. M. Thrombolytics and myocardial infarction. Cardiovascular Therapeutics, v. 30, n. 2, p.e81-e88, 2012. doi: https://doi.org/10.1111/j.1755-5922.2010.00239.x

MADAN, M. et al. Relationship between time to invasive assessment and clinical outcomes of patients undergoing an early invasive strategy after fibrinolysis for ST-segment elevation myocardial infarction: a patient-level analysis of the randomized early routine invasive clinical trials. JACC Cardiovascular Interventions, v. 8, (1 Pt B), p.166-174, 2015. doi: https://doi.org/10.1016/j.jcin.2014.09.005

MORRISON, L. J. et. al. Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis. JAMA, v. 283, n. 20, p.2686-2692, 2000. doi: https://doi.org/10.1001/jama.283.20.2686

NASCIMENTO, B. R. et al. Cardiovascular disease epidemiology in portuguese-speaking countries: data from the Global Burden of Disease, 1990 to 2016. Arquivos Brasileiros de Cardiologia, v. 110, n. 6, p.500-511, 2018. doi: https://doi.org/10.5935/abc.20180098

OLIVEIRA, G. M. M. et al. Estatística Cardiovascular – Brasil 2020. Arquivos Brasileiros de Cardiologia, v. 115, n. 3, p.308-439, 2020. doi: https://doi.org/10.36660/abc.20200812

OLIVEIRA, J. C. et al. Acesso à Terapia de Reperfusão e Mortalidade em Mulheres com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST: Registro VICTIM. Arquivos Brasileiros de Cardiologia, v. 116, n. 4, p.695-703, 2021. doi: https://doi.org/10.36660/abc.20190468

PIEGAS, L. S. et al. Sociedade Brasileira de Cardiologia. V Diretriz da Sociedade Brasileira de Cardiologia sobre Tratamento do Infarto Agudo do Miocárdio com Supradesnível do Segmento ST. Arquivos Brasileiros de Cardiologia, v. 105, n. 2, p.1-105, 2015. doi: https://doi.org/10.5935/abc.20150107

PINTO, D. S. et al. Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase. Circulation, v. 124, n. 23, p.2512-2521, 2011. doi: https://doi.org/10.1161/CIRCULATIONAHA.111.018549

ROFFI, M. et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). European Heart Journal, v. 37, p. 267–315, 2016. doi: https://doi.org/10.1093/eurheartj/ehv320

ROULE, V. et al. Prehospital fibrinolysis versus primary percutaneous coronary intervention in ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. Critical Care, v. 20, n. 359, p.1-7, 2016. doi: https://doi.org/10.1186/s13054-016-1530-z

SINNAEVE, P. R. et al. STREAM Investigators. ST-segment-elevation myocardial infarction patients randomized to a pharmaco-invasive strategy or primary percutaneous coronary intervention: Strategic Reperfusion Early After Myocardial Infarction (STREAM) 1-year mortality follow-up. Circulation, v. 130, n. 14, p.1139-1145, 2014. doi: https://doi.org/10.1161/CIRCULATIONAHA.114.009570

TERKELSEN, C. J. et al. System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. JAMA, v. 304, n. 7, p.763-771, 2010. doi: https://doi.org/10.1001/jama.2010.1139

The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. New England Journal of Medicine, v. 329, n. 10, p.673-682, 1993. doi: https://doi.org/10.1056/nejm199309023291001

THYGESEN, K. et al. Fourth Universal Definition of Myocardial Infarction (2018). European Heart Journal, v. 40, n. 3, p.237-69, 2019. doi: https://doi.org/10.1161/cir.0000000000000617

VAN DE WERF, F. et al. Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. The Lancet, v. 354, n. 9180, p.716-722, ago. 1999. doi: https://doi.org/10.1016/s0140-6736(99)07403-6

WEAVER, W. D. et al. Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review. JAMA, v. 278, n. 23, p.2093-8, 1997. doi: https://doi.org/10.1001/jama.1997.03550230069040

Downloads

Publicado

2024-08-31

Como Citar

Zulin, M. E. G., Ferreira Júnior, M. A. ., Fernandes Meireles Câmara, P. ., Pereira Frota, O., Neris Fereira Sarat, C. ., & Souza Goldiano, J. A. (2024). Complications of Tenecteplase in pre-hospital care for treatment of acute myocardial infarction: Complicações do uso pré-hospitalar da Tenecteplase para tratamento do Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST. Concilium, 24(17), 246–262. Recuperado de http://clium.org/index.php/edicoes/article/view/4059

Edição

Seção

Articles