Oral manifestations of COVID-19 in children: a narrative literature review
Manifestações orais da COVID-19 em crianças: uma revisão narrativa de literatura
Palavras-chave:
Oral manifestation, COVID-19, childrenResumo
COVID-19 triggers an acute inflammatory response in organs, tissues, tongue mucosa, and salivary glands. Some symptoms such as lesions on the tongue and oral mucosa, oral pseudomembranous candidiasis, pharyngitis, taste alteration, gingivitis, canker sores, and even multisystem inflammatory syndrome have been reported in children with COVID-19. Early diagnosis of oral manifestations improves patients' prognosis and quality of life. A narrative literature review was conducted based on studies published in PubMed and LiLacs from January 2020 to April 2024, related to oral manifestations in COVID-19 in children. Of the 68 articles found, 7 were selected after analysis. The main manifestations presented were: abscesses, mucositis, ulcerative lesions, gingivitis, pseudomembranous candidiasis, mucosal lesions, lip and tongue fissures, hemorrhagic crust, inflammation of salivary glands, lip swelling, and reactive infectious mucocutaneous eruption. The selected articles showed that these oral manifestations of COVID-19 can affect children in various age groups, serving as indicators of the disease and signs of worsening infection.
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ABDELMASSIH A, Gadalla M, Hussein E, Elahmady M, Zahra N, Eid MA, Hussein M, Hassan AA, Abou-Zeid AS, Hassan A, El Nahhas N, Emad N, Aboushadi N, Ibrahim N, Mokhtar S, El-Husseiny N, Kamel A, Hozaien R, Menshawey E, Ismail HA, Mokhles M, Menshawey R, Fouda R. O transplante microbiano oral esquecido para melhorar os resultados de COVID-19. 2021 Set;43:100923. DOI: 10.1016/j.nmni.2021.100923. EPub 2021 24 jul. PMID: 34336224; PMCID: PMC8310390.
BARDELLINI E, Bondioni MP, Amadori F, Veneri F, Lougaris V, Meini A, Plebani A, Majorana A. Manifestações orais e cutâneas inespecíficas da doença do coronavírus 2019 em crianças. Med Oral Patol Oral Cir Bucal. 1º de setembro de 2021; 26(5):e549-e553. DOI: 10.4317/medoral.24461. PMID: 33772567; PMCID: PMC8412440.
BOSHRA M, Ghazawi FM, Liy-Wong C. Treatment of coronavirus disease 2019-associated mucositis in adolescents: A case report and brief literature review. SAGE Open Med Case Rep. 2023 Dec 4;11:2050313X231212985. doi: 10.1177/2050313X231212985. PMID: 38059177; PMCID: PMC10697032.
CHENG, Hao-Yuan et al. Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset. JAMA internal medicine, v. 180, n. 9, p. 1156-1163, 2020.
CREDIE, G. B., Coelho, A. A., & Rezende, K. M. (2020). Coronavirus (COVID-19) in children: history and pediatric oral health. Dental Oral biology and craniofacial research, 3(3), 3. doi:http://dx.doi.org/10.31487/j.DOBCR.2020.03.06
DE FELICE, Francesca; POLIMENI, Antonella. Coronavirus disease (COVID-19): a machine learning bibliometric analysis. in vivo, v. 34, n. 3 suppl, p. 1613-1617, 2020.
HALEPAS S, Lee KC, Myers A, Yoon RK, Chung W, Peters SM. Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children: a review of 47 pediatric patients. J Am Dent Assoc. 2021 Mar;152(3):202-208. doi: 10.1016/j.adaj.2020.11.014. Epub 2020 Dec 9. PMID: 33632409; PMCID: PMC7832615.
JASSO, Yunuhen; Belmont Laguna, Francisco; Vázquez de Lara Saavedra, Lucero; Peral García, Alejandra Oral manifestations and stomatological management of pediatric patients with sequelae due to COVID-19.. Rev. odontopediatr. latinoam ; 12(1): 214376, 2022. graf, ilus
MARIZ BALA, Brandão TB, Ribeiro ACP, Lopes MA, Santos-Silva AR. 2020. Novos insights para a patogênese da disgeusia COVID-19-relacionada. J Dent Res. 99(10):1206.
MOCA AE, Juncar RI, Moca RT, Bota T, Sabău DT, Juncar M. Oral Manifestations in Children Diagnosed with COVID-19: A Narrative Review. Healthcare (Basel). 2023 Jan 17;11(3):288. doi: 10.3390/healthcare11030288. PMID: 36766863; PMCID: PMC9914393.
MURTHY, Srinivas; GOMERSALL, Charles D.; FOWLER, Robert A. Care for critically ill patients with COVID-19. Jama, v. 323, n. 15, p. 1499-1500, 2020.
NASCIMENTO RB, Araújo NS, Silva JC, Xavier FCA. Manifestações orais da síndrome inflamatória multissistêmica em crianças (MIS-C) e doença de Kawasaki associada à COVID-19: Uma revisão sistemática. Spec Care Dentista. Maio de 2022; 42(3):266-280. DOI: 10.1111/scd.12669. EPub 2021 18 de novembro. PMID: 34792813; PMCID: PMC8662078.
NASIRI K, Tehrani S, Mohammadikhah M, Banakar M, Alaeddini M, Etemad-Moghadam S, Fernandes GVO, Heboyan A, Imannezhad S, Abbasi F. Oral manifestations of COVID-19 and its management in pediatric patients: A systematic review and practical guideline. Clin Exp Dent Res. 2023 Oct;9(5):922-934. doi: 10.1002/cre2.776. Epub 2023 Aug 21. PMID: 37602892; PMCID: PMC10582234.
ÖZEN T, Kahraman FC, Öcal S, Ovalı HF. Achados de pele, mucosas e unhas em pacientes pediátricos hospitalizados com doença por Coronavirus-2019 (COVID-19). Um sutiã dermatol. 2023 Mar-Abr; 98(2):208-215. DOI: 10.1016/j.abd.2022.03.006. EPub 2022 23 de novembro. PMID: 36435635; PMCID: PMC9682411.
RIAD A, Boccuzzi M, Sagiroglu D, Klugar M, Krsek M. Pediatric multisystem inflammatory syndrome temporally associated with SARS-COV-2: Oral manifestations and implications. Int J Paediatr Dent. 2021 Jan;31(1):35-36. doi: 10.1111/ipd.12694. Epub 2020 Aug 21. PMID: 32767455; PMCID: PMC7436594.
SANTOS NMVD, Brito DHS, Santos TGFTD, Silva MCPMD, Lavôr JR, Heimer MV, Rosenblatt A. Oral manifestations in hospitalized children with COVID-19. Braz Oral Res. 2022 Dec 2;36:e139. doi: 10.1590/1807-3107bor-2022.vol36.0139. PMID:36477216.
TAVARES, N. C. dos S. A.; Oliveira, E. M.; Ribeiro, A. K.; Imparato, J. C. P.; Rezende, K. M. Sinais e sintomas de manifestações orais e cutâneas em crianças com COVID-19: revisão narrativa. Pesquisa, Sociedade e Desenvolvimento, [S. l.], v. 10, n. 10, p. e258101018515, 2021. DOI: 10.33448/rsd-v10i10.18515.
THEVARAJAN, Irani et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nature medicine, v. 26, n. 4, p. 453-455, 2020.
WANG, Bolin et al. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (albany NY), v. 12, n. 7, p. 6049, 2020.
WISE, Jacqui. Covid-19: WHO declares end of global health emergency. 2023.
XU H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T, Chen Q. 2020. Alta expressão do receptor ACE2 do 2019-nCoV nas células epiteliais da mucosa oral. Int J Oral Sci. 12(1):8
ZOU X, Chen K, Zou J, Han P, Hao J, Han Z. 2020. A análise de dados de RNA-seq de célula única na expressão do receptor ACE2 revela o risco potencial de diferentes órgãos humanos vulneráveis à infecção por 2019-nCoV. Frente Med. 14(2):185–192.
