Alzheimer's disease: therapeutic potential of phytocannabinoids
Doença de Alzheimer: potencial terapêutico dos fitocanabinoide
Resumo
Alzheimer's Disease is a progressive neurodegenerative condition that results in cognitive decline and behavioral changes. This article aims to analyze the therapeutic potential of phytocannabinoids in Alzheimer's Disease. We conducted a systematic search of articles published from 2014 to May 2024 in the MEDLINE (PubMed), LILACS, and SCOPUS databases, using terms related to Alzheimer's Disease, neuroinflammation, endocannabinoid system, phytocannabinoids, cannabis, cannabinoid, cannabidiol, and delta-9-tetrahydrocannabinol. The results of this systematic review provide a comprehensive overview of the interaction between neurodegeneration and the endocannabinoid system, highlighting the potential of phytocannabinoids as therapeutic interventions for Alzheimer's Disease.
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Referências
ABATE G, UBERTI D, TAMBARO S. Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy. Biology (Basel). 2021 Jun 17;10(6):542. doi: 10.3390/biology10060542. PMID: 34204237; PMCID: PMC8234911.
ABUBAKAR MB, SANUSI KO, UGUSMAN A, MOHAMED W, KAMAL H, IBRAHIM NH, KHOO CS, KUMAR J. Alzheimer's Disease: An Update and Insights into Pathophysiology. Front Aging Neurosci. 2022 Mar 30; 14:742408. doi: 10.3389/fnagi.2022.742408. PMID: 35431894; PMCID: PMC9006951.
ACHARI AE, JAIN SK. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction. Int J Mol Sci. 2017 Jun 21;18(6):1321. doi: 10.3390/ijms18061321. PMID: 28635626; PMCID: PMC5486142.
ACHARYA N, PENUKONDA S, SHCHEGLOVA T, HAGYMASI AT, BASU S, SRIVASTAVA PK. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci U S A. 2017 May 9;114(19):5005-5010. doi: 10.1073/pnas.1612177114. Epub 2017 Apr 24. PMID: 28439004; PMCID: PMC5441729.
AIZPURUA-OLAIZOLA O, ELEZGARAI I, RICO-BARRIO I, ZARANDONA I, ETXEBARRIA N, USOBIAGA A. Targeting the endocannabinoid system: future therapeutic strategies. Drug Discov Today. 2017 Jan;22(1):105-110. doi: 10.1016/j.drudis.2016.08.005. Epub 2016 Aug 20. PMID: 27554802.
ALLENDE G, CHÁVEZ-REYES J, GUERRERO-ALBA R, VÁZQUEZ-LEÓN P, MARICHAL-CANCINO BA. Advances in Neurobiology and Pharmacology of GPR12. Front Pharmacol. 2020 May 8; 11:628. doi: 10.3389/fphar.2020.00628. PMID: 32457622; PMCID: PMC7226366.
ALZHEIMER´S ASSOCIATION: acesso em 11 de maio de 2024/. https://www.alz.org/alzheimer_s_dementia
ASO E, ANDRÉS-BENITO P, CARMONA M, MALDONADO R, FERRER I. Cannabinoid Receptor 2 Participates in Amyloid-β Processing in a Mouse Model of Alzheimer's Disease but Plays a Minor Role in the Therapeutic Properties of a Cannabis-Based Medicine. J Alzheimers Dis. 2016;51(2):489-500. doi: 10.3233/JAD-150913. PMID: 26890764.
ASO E, FERRER I. Cannabinoids for treatment of Alzheimer's disease: Moving Toward the clinic. Front Pharmacol. 2014 Mar 5; 5:37. doi: 10.3389/fphar.2014.00037. PMID: 24634659; PMCID: PMC3942876.
BASAVARAJAPPA BS, SHIVAKUMAR M, JOSHI V, SUBBANNA S. Endocannabinoid system in neurodegenerative disorders. J Neurochem. 2017 Sep;142(5):624-648. doi: 10.1111/jnc.14098. Epub 2017 Jul 5. PMID: 28608560; PMCID: PMC5669051.
BIEGER A, ROCHA A, BELLAVER B, MACHADO L, DA ROS L, BORELLI WV, THERRIAULT J, MACEDO AC, PASCOAL TA, GAUTHIER S, ROSA-NETO P, ZIMMER ER. Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer's Disease Continuum. J Prev Alzheimers Dis. 2023;10(3):401-417. doi: 10.14283/jpad.2023.54. PMID: 37357281.
BILLMANN, Ariane; PEZZINI, Marina Ferri; POETA, Julia. Biomarcadores no líquido cefalorraquidiano no desenvolvimento da doença de Alzheimer: uma revisão sistemática. Rev. Psicol. Saúde, Campo Grande, v. 12, n. 2, p. 141-153, jun. 2020. https://doi.org/10.20435/pssa.v0i0.927.
BONDARENKO AI. Endothelial atypical cannabinoid receptor: do we have enough evidence? Br J Pharmacol. 2014 Dec;171(24):5573-88. doi: 10.1111/bph.12866. PMID: 25073723; PMCID: PMC4290703.
CACACE R, SLEEGERS K, VAN BROECKHOVEN C. Molecular genetics of early-onset Alzheimer's disease revisited. Alzheimers Dement. 2016 Jun;12(6):733-48. doi: 10.1016/j.jalz.2016.01.012. Epub 2016 Mar 24. PMID: 27016693.
CAI Y, LIU J, WANG B, SUN M, YANG H. Microglia in the Neuroinflammatory Pathogenesis of Alzheimer's Disease and Related Therapeutic Targets. Front Immunol. 2022 Apr 26; 13:856376. doi: 10.3389/fimmu.2022.856376. PMID: 35558075; PMCID: PMC9086828.
CAI Z, HUSSAIN MD, YAN LJ. Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease. Int J Neurosci. 2014 May;124(5):307-21. doi: 10.3109/00207454.2013.833510. Epub 2013 Sep 12. PMID: 23930978.
CAMARGO FILHO M F A; ROMANINI A P; PYRICH, B C; PEDRI E; FONTOURA G C; ZORRER L A; GONÇALVES V D M A; GIANINI V C M; MÜLLER J C. Canabinoides como uma nova opção terapêutica nas doenças de Parkinson e de Alzheimer: uma revisão de literatura / Canabinoid as a new therapeutic option in Parkinson's and Alzheimer's diseases: a literature review Rev. brasileira neurologia ; 55(2): 17-32, abr.-jun. 2019. doi.org/10.46979/rbn. v55i2.26911
CAO C, LI Y, LIU H, BAI G, MAYL J, LIN X, SUTHERLAND K, NABAR N, CAI J. The potential therapeutic effects of THC on Alzheimer's disease. J Alzheimers Dis. 2014;42(3):973-84. doi: 10.3233/JAD-140093. PMID: 25024327.
CARVAJAL CARVAJAL, C. Biología molecular de la enfermedad de Alzheimer. Costa Rica, Heredia, v. 33, n. 2, p. 104-122, dezembro de 2016. Disponível em <http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409 00152016000200104&lng=en&nrm=iso>. acesso em 23 de maio de 2024.
CASTELLANI R J., PLASCENCIA-VILLA G, PERRY G. The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation. Laboratory Investigation Volume 99 Issue 7 Pages 958-970 (July 2019) DOI: 10.1038/s41374-019-0231-z
COLES M, STEINER-LIM GZ, KARL T. Therapeutic properties of multi-cannabinoid treatment strategies for Alzheimer's disease. Front Neurosci. 2022 Sep 2; 16:962922. doi: 10.3389/fnins.2022.962922. PMID: 36117622; PMCID: PMC9479694.
CRIPPA, J. A. S., GUIMARÃES, F. S., ZUARDI, A. W., & HALLAK, J. E. C. (2023). Dr. Raphael Mechoulam, cannabis and cannabinoids research pioneer (November 5, 1930–March 9, 2023) and his legacy for Brazilian pharmacology. Brazilian Journal of Psychiatry, 45(3), 201–202. https://doi.org/10.47626/1516-4446-2023-0047
CRISTINO L, BISOGNO T, DI MARZO V. Cannabinoids and the expanded endocannabinoid system in neurological disorders. Nat Rev Neurol. 2020 Jan;16(1):9-29. doi: 10.1038/s41582-019-0284-z. Epub 2019 Dec 12. PMID: 31831863.
DE CASTRO, A. A., Soares, F. V., Pereira, A. F., Polisel, D. A., Caetano, M. S., Leal, D. H. S., Ramalho, T. C. (2019). Compostos não convencionais com potenciais efeitos terapêuticos contra a doença de Alzheimer. Revisão de Especialistas em Neuroterapêutica, 19(5), 375–395. https://doi.org/10.1080/14737175.2019.1608823
DE STROOPER B, KARRAN E. The Cellular Phase of Alzheimer's Disease. Cell. 2016 Feb 11;164(4):603-15. doi: 10.1016/j.cell.2015.12.056. PMID: 26871627.
DELANOGARE, E., FLORES, D., DE SOUZA, R. M., DE SOUZA, L., & GASNHAR MOREIRA, E. L. (2019). Hipótese amiloide e o tratamento da doença de Alzheimer: revisão dos estudos clínicos realizados. VITTALLE - Revista De Ciências Da Saúde, 31(1), 84–106. https://doi.org/10.14295/vittalle.v31i1.8395
DI FEDE G, GIACCONE G, SALMONA M, TAGLIAVINI F. Translational Research in Alzheimer's and Prion Diseases. J Alzheimers Dis. 2018;62(3):1247-1259. doi: 10.3233/JAD-170770. PMID: 29172000; PMCID: PMC5869996.
DIONISIO-SANTOS DA OLSCHOWKA JA, O'BANION MK. Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease. J Neuroinflammation. 2019 Apr 5;16(1):74. doi: 10.1186/s12974-019-1453-0. PMID: 30953557; PMCID: PMC6449993.
DORSZEWSKA J, PRENDECKI M, OCZKOWSKA A, DEZOR M, KOZUBSKI W. Molecular Basis of Familial and Sporadic Alzheimer's Disease. Curr Alzheimer Res. 2016;13(9):952-63. doi: 10.2174/1567205013666160314150501. PMID: 26971934.
ENGELHARDT E, GRINBERG LT. Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain. Dement Neuropsychol. 2015 Jan-Mar;9(1):81-84. doi: 10.1590/S1980-57642015DN91000013. PMID: 29213946; PMCID: PMC5618996.
ERATNE, D., LOI, S. M., FARRAND, S., KELSO, W., VELAKOULIS, D., & LOOI, J. C. (2018). Alzheimer's disease: clinical update on epidemiology, pathophysiology anddiagnosis. Australasian psychiatry: bulletin of Royal Australian and New Zealand College of Psychiatrists, 26(4), 347–357.https://doi.org/10.1177/103985621876230
FALCO AD, CUKIERMAN DS, HAUSER-DAVIS RA, REY NA. Doença de Alzheimer: hipóteses etiológicas e perspectivas de tratamento." (“Multisite transcranial direct current stimulation associated with ...”) Quím Nova [Internet]. 2016 Jan;39(1):63–80. Available from: https://doi.org/10.5935/0100-4042.20150152.
FERRARI C, SORBI S. The complexity of Alzheimer's disease: an evolving puzzle. Physiol Rev. 2021 Jul 1;101(3):1047-1081. doi: 10.1152/physrev.00015.2020. Epub 2021 Jan 21. PMID: 33475022
FERREIRA MC, TOZATTI J, FACHIN SM, OLIVEIRA PP, SANTOS RF, SILVA ME. Redução da mobilidade funcional e da capacidade cognitiva no diabetes melito tipo 2 [Reduction of functional mobility and cognitive capacity in type 2 diabetes mellitus]. Arq Bras Endocrinol Metabol. 2014 Dec;58(9):946-52. Portuguese. doi: 10.1590/0004-2730000003097. PMID: 25627051.
FUMAGALLI GG, BASILICO P, ARIGHI A, MERCURIO M, SCARIONI M, CARANDINI T, COLOMBI A, PIETROBONI AM, SACCHI L, CONTE G, SCOLA E, TRIULZI F, SCARPINI E, GALIMBERTI D. Parieto-occipital sulcus widening differentiates posterior cortical atrophy from typical Alzheimer disease. Neuroimage Clin. 2020; 28:102453. doi: 10.1016/j.nicl.2020.102453. PMID: 33045537; PMCID: PMC7559336.
GAUTHIER S, ROSA-NETO P, MORAIS JA, WEBSTER C. World Alzheimer Report 2021: Journey through the diagnosis of dementia. London: Alzheimer’s Disease International (UK); 2021. 313 p
GOURE WF, KRAFFT GA, JERECIC J, HEFTI F. Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics. Alzheimers Res Ther. 2014 Jul 9;6(4):42. doi: 10.1186/alzrt272. PMID: 25045405; PMCID: PMC4100318.
GÜLCK T, MØLLER BL. Phytocannabinoids: Origins and Biosynthesis. Trends Plant Sci. 2020 Oct;25(10):985-1004. doi: 10.1016/j.tplants.2020.05.005. Epub 2020 Jul 6. PMID: 32646718.
GUTTENPLAN KA, WEIGEL MK, PRAKASH P, WIJEWARDHANE PR, HASEL P, RUFEN-BLANCHETTE U, MÜNCH AE, BLUM JA, FINE J, NEAL MC, BRUCE KD, GITLER AD, CHOPRA G, LIDDELOW SA, BARRES BA. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021 Nov;599(7883):102-107. doi: 10.1038/s41586-021-03960-y. Epub 2021 Oct 6. PMID: 34616039.
HALLIDAY G, ROBINSON SR, SHEPHERD C, KRIL J. Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol. 2000 Jan-Feb;27(1-2):1-8. doi: 10.1046/j.1440-1681.2000.03200. x. PMID: 10696521.
HAMPEL H, ELHAGE A, CHO M, APOSTOLOVA LG, NICOLL JAR, ATRI A. Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics. Brain. 2023 Nov 2;146(11):4414-4424. doi: 10.1093/brain/awad188. PMID: 37280110; PMCID: PMC10629981.
HAMPEL H, MESULAM MM, CUELLO AC, FARLOW MR, GIACOBINI E, GROSSBERG GT, KHACHATURIAN AS, VERGALLO A, CAVEDO E, SNYDER PJ, KHACHATURIAN ZS. The cholinergic system in the pathophysiology and treatment of Alzheimer's disease. Brain. 2018 Jul 1;141(7):1917-1933. doi: 10.1093/brain/awy132. PMID: 29850777; PMCID: PMC6022632.
HANUŠ LO, MEYER SM, MUÑOZ E, TAGLIALATELA-SCAFATI O, APPENDINO G. Phytocannabinoids: a unified critical inventory. Nat Prod Rep. 2016 Nov 23;33(12):1357-1392. doi: 10.1039/c6np00074f. PMID: 27722705.
HANUŠ LO, HOD Y. Terpenos/terpenóides em cannabis: são importantes? Med Cannabis canabinóides. 10 de agosto de 2020; 3(1):25-60. DOI: 10.1159/000509733. PMID: 34676339; PMCID: PMC8489319.
HARDY JA, HIGGINS GA. Alzheimer's disease: the amyloid cascade hypothesis. Science. 1992 Apr 10;256(5054):184-5. doi: 10.1126/science.1566067. PMID: 1566067.
HASHIMOTO Y, MATSUOKA M. A mutation protective against Alzheimer's disease renders amyloid β precursor protein incapable of mediating neurotoxicity. J Neurochem. 2014 Jul;130(2):291-300. doi: 10.1111/jnc.12717. Epub 2014 Apr 10. PMID: 24646423.
HOURFANE S, MECHQOQ H, BEKKALI AY, ROCHA JM, EL AOUAD N. A Comprehensive Review on Cannabis sativa Ethnobotany, Phytochemistry, Molecular Docking and Biological Activities. Plants (Basel). 2023 Mar 9;12(6):1245. doi: 10.3390/plants12061245. PMID: 36986932; PMCID: PMC10058143.
HUANG Y, MAHLEY RW. Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases. Neurobiol Dis. 2014 Dec;72 Pt A:3-12. doi: 10.1016/j.nbd.2014.08.025. Epub 2014 Aug 27. PMID: 25173806; PMCID: PMC4253862.
INSTITUTE OF HEALTH METRICS [homepage na Internet]. Brasil. 2018 [conectado 12/05/2024] disponível » http://www.healthdata.org/brazil
KARL T, GARNER B, CHENG D. The therapeutic potential of the phytocannabinoid cannabidiol for Alzheimer's disease. Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):142-160. doi: 10.1097/FBP.0000000000000247. PMID: 27471947.
KASATKINA LA, RITTCHEN S, STURM EM. Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation. Int J Mol Sci. 2021 May 21;22(11):5431. doi: 10.3390/ijms22115431. PMID: 34063947; PMCID: PMC8196612.
LAVADO LK, ZHANG MH, PATEL K, KHAN S, PATEL UK. Bimetals as Potential Predictors of the Neurodegenerative Decline in Alzheimer's Disease. Cureus. 2019 Sep 5;11(9): e5573. doi: 10.7759/cureus.5573. PMID: 31695992; PMCID: PMC6820671.
LI X, HUA T, VEMURI K, HO JH, WU Y, WU L, POPOV P, BENCHAMA O, ZVONOK N, LOCKE K, QU L, HAN GW, IYER MR, CINAR R, COFFEY NJ, WANG J, WU M, KATRITCH V, ZHAO S, KUNOS G, BOHN LM, MAKRIYANNIS A, STEVENS RC, LIU ZJ. Crystal Structure of the Human Cannabinoid Receptor CB2. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. PMID: 30639103; PMCID: PMC6713262.
LIDDELOW SA, GUTTENPLAN KA, CLARKE LE, BENNETT FC, BOHLEN CJ, SCHIRMER L, BENNETT ML, MÜNCH AE, CHUNG WS, PETERSON TC, WILTON DK, FROUIN A, NAPIER BA, PANICKER N, KUMAR M, BUCKWALTER MS, ROWITCH DH, DAWSON VL, DAWSON TM, STEVENS B, BARRES BA. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029. Epub 2017 Jan 18. PMID: 28099414; PMCID: PMC5404890.
LOWE H, TOYANG N, STEELE B, BRYANT J, NGWA W. The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases. Int J Mol Sci. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472. PMID: 34502379; PMCID: PMC8430969.
LUCA A, CALANDRA C, LUCA M. Molecular Bases of Alzheimer's Disease and Neurodegeneration: The Role of Neuroglia. Aging Dis. 2018 Dec 4;9(6):1134-1152. DOI: 10.14336/AD.2018.0201. PMID: 30574424; PMCID: PMC6284765.
MANGALMURTI A, LUKENS JR. How neurons die in Alzheimer's disease: Implications for neuroinflammation. Curr Opin Neurobiol. 2022 Aug; 75:102575. doi: 10.1016/j.conb.2022.102575. Epub 2022 Jun 10. PMID: 35691251; PMCID: PMC9380082.
MECHA M, CARRILLO-SALINAS FJ, FELIÚ A, MESTRE L, GUAZA C. Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacol Ther. 2016 Oct; 166:40-55. doi: 10.1016/j.pharmthera.2016.06.011. Epub 2016 Jun 29. PMID: 27373505.
MECHOULAM R, GAONI Y. A TOTAL SYNTHESIS OF DL-DELTA-1-TETRAHYDROCANNABINOL, THE ACTIVE CONSTITUENT OF HASHISH. J Am Chem Soc. 1965 Jul 20; 87:3273-5. doi: 10.1021/ja01092a065. PMID: 14324315.
MENDEZ MF. Early-Onset Alzheimer Disease. Neurol Clin. 2017 May;35(2):263-281. doi: 10.1016/j.ncl.2017.01.005. PMID: 28410659; PMCID: PMC5407192.
MORIOKA S, PERRY JSA, RAYMOND MH, MEDINA CB, ZHU Y, ZHAO L, SERBULEA V, ONENGUT-GUMUSCU S, LEITINGER N, KUCENAS S, RATHMELL JC, MAKOWSKI L, RAVICHANDRAN KS. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature. 2018 Nov;563(7733):714-718. doi: 10.1038/s41586-018-0735-5. Epub 2018 Nov 21. PMID: 30464343; PMCID: PMC6331005.
MUENCHHOFF J, POLJAK A, SONG F, RAFTERY M, BRODATY H, DUNCAN M, MCEVOY M, ATTIA J, SCHOFIELD PW, SACHDEV PS. Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts. J Alzheimers Dis. 2015;43(4):1355-73. doi: 10.3233/JAD-141266. PMID: 25159666.
MURATAEVA N, STRAIKER A, MACKIE K. Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. Br J Pharmacol. 2014 Mar;171(6):1379-91. doi: 10.1111/bph.12411. PMID: 24102242; PMCID: PMC3954479.
ORTA-SALAZAR E, CUELLAR-LEMUS CA, DÍAZ-CINTRA S, FERIA-VELASCO AI. Cholinergic markers in the cortex and hippocampus of some animal species and their correlation to Alzheimer's disease. Neurologic. 2014 Oct;29(8):497-503. English, Spanish. doi: 10.1016/j.nrl.2012.10.007. Epub 2013 Feb 22. PMID: 23433740.
PAPAGIANNI EP, STEVENSON CW. Cannabinoid Regulation of Fear and Anxiety: an Update. Curr Psychiatry Rep. 2019 Apr 27;21(6):38. doi: 10.1007/s11920-019-1026-z. PMID: 31030284; PMCID: PMC6486906.
PRINZ M, PRILLER J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease." (“JCI - Microglia in steady state”) Nat Rev Neurosci. 2014 May;15(5):300-12. doi: 10.1038/nrn3722. Epub 2014 Apr 9. PMID: 24713688.
RANIERI R, LAEZZA C, BIFULCO M, MARASCO D, MALFITANO AM. Endocannabinoid System in Neurological Disorders. Recent Pat CNS Drug Discov. 2016;10(2):90-112. doi: 10.2174/1574889810999160719105433. PMID: 27364363.
REEMST K, NOCTOR SC, LUCASSEN PJ, HOL EM. The Indispensable Roles of Microglia and Astrocytes during Brain Development. Front Hum Neurosci. 2016 Nov 8; 10:566. doi: 10.3389/fnhum.2016.00566. PMID: 27877121; PMCID: PMC5099170.
REITZ C, ROGAEVA E, BEECHAM GW. Late-onset vs nonmendelian early-onset Alzheimer disease: A distinction without a difference? Neurol Genet. 2020 Oct 6;6(5):e512. doi: 10.1212/NXG.0000000000000512. PMID: 33225065; PMCID: PMC7673282.
REZENDE B, ALENCAR AKN, DE BEM GF, FONTES-DANTAS FL, MONTES GC. Endocannabinoid System: Chemical Characteristics and Biological Activity. Pharmaceuticals (Basel). 2023 Jan 19;16(2):148. doi: 10.3390/ph16020148. PMID: 37017445; PMCID: PMC9966761.
RIBEIRO, HELEM F.; DOS SANTOS, JÉSSICA SCARLET F; DE SOUZA, JULYANNE N. Doença de Alzheimer de início precoce (DAIP): características neuropatológicas e variantes genéticas associadas. Rev Neuropsiquiatria, Lima, v. 84, n. 2, p. 113-127, abr. 2021; http://dx.doi.org/10.20453/rnp.v84i2.3998.
ROJAS M, CHÁVEZ-CASTILLO M, BAUTISTA J, ORTEGA Á, NAVA M, SALAZAR J, DÍAZ-CAMARGO E, MEDINA O, ROJAS-QUINTERO J, BERMÚDEZ V. Alzheimer's disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links. World J Diabetes. 2021 Jun 15;12(6):745-766. doi: 10.4239/wjd. v12.i6.745. PMID: 34168725; PMCID: PMC8192246.
SCHILLING LP, BALTHAZAR MLF, RADANOVIC M, FORLENZA OV, SILAGI ML, SMID J, BARBOSA BJAP, FROTA NAF, DE SOUZA LC, VALE FAC, CARAMELLI P, BERTOLUCCI PHF, CHAVES MLF, BRUCKI SMD, DAMASCENO BP, NITRINI R. Diagnosis of Alzheimer's disease: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Dement Neuropsychol. 2022 Nov 28;16(3 Suppl 1):25-39. doi: 10.1590/1980-5764-DN-2022-S102 PT. PMID: 36533157; PMCID: PMC9745995
SELKOE DJ, HARDY J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. PMID: 27025652; PMCID: PMC4888851.
SHARMA P, SRIVASTAVA P, SETH A, TRIPATHI PN, BANERJEE AG, SHRIVASTAVA SK. Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies. Prog Neurobiol. 2019 Mar; 174:53-89. doi: 10.1016/, Dec 30. PMID: 30599179.
SINGH A, KUKRETI R, SASO L, KUKRETI S. Oxidative Stress: A Key Modulator in Neurodegenerative Diseases. Molecules. 2019 Apr 22;24(8):1583. doi: 10.3390/molecules24081583. PMID: 31013638; PMCID: PMC6514564.
SOLOMON A, TURUNEN H, NGANDU T, PELTONEN M, LEVÄLAHTI E, HELISALMI S, ANTIKAINEN R, BÄCKMAN L, HÄNNINEN T, JULA A, LAATIKAINEN T, LEHTISALO J, LINDSTRÖM J, PAAJANEN T, PAJALA S, STIGSDOTTER-NEELY A, STRANDBERG T, TUOMILEHTO J, SOININEN H, KIVIPELTO M. Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial. JAMA Neurol. 2018 Apr 1;75(4):462-470. doi: 10.1001/jamaneurol.2017.4365. PMID: 29356827; PMCID: PMC5885273.
STELZMANN, R.A., NORMAN SCHNITZLEIN, H. AND REED MURTAGH, F. (1995), An english translation of Alzheimer’s 1907 paper, “Uber eine eigenartige erkankung der hirnrinde”. Clin. Anat., 8: 429-431. https://doi.org/10.1002/ca.980080612
STITH, S.S., LI, X., DIVIANT, J.P. et al. A eficácia da flor de Cannabis inalada para o tratamento da agitação/irritabilidade, ansiedade e estresse comum. J Cannabis Res 2, 47 (2020). https://doi.org/10.1186/s42238-020-00051-z
STROOPER B.D, KARRAN E. The Cellular Phase of Alzheimer’s Disease, Cell, Vol. 164, Issue 4, 2016, Pag. 603-615, https://doi.org/10.1016/j.cell.2015.12.056.
TETER B, MORIHARA T, LIM GP, CHU T, JONES MR, ZUO X, PAUL RM, FRAUTSCHY SA, COLE GM. Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis. Neurobiol Dis. 2019 Jul; 127:432-448. doi: 10.1016/j.nbd.2019.02.015. Epub 2019 Apr 2. PMID: 30951849; PMCID: PMC8092921.
TIWARI S, ATLURI V, KAUSHIK A, YNDART A, NAIR M. Alzheimer's disease: pathogenesis, diagnostics, and therapeutics. Int J Nanomedicine. 2019 Jul 19; 14:5541-5554. doi: 10.2147/IJN.S200490. PMID: 31410002; PMCID: PMC6650620.
TREJO-LOPEZ JA, YACHNIS AT, PROKOP S. Neuropathology of Alzheimer's Disease. Neurotherapeutics. 2022 Jan;19(1):173-185. doi: 10.1007/s13311-021-01146-y. Epub 2021 Nov 2. PMID: 34729690; PMCID: PMC9130398.
VAZ FNC, FERMINO BL, HASKEL MVL, WOUK J, DE FREITAS GBL, FABBRI R, MONTAGNA E, ROCHA JBT, BONINI JS. The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease. Biol Trace Elem Res. 2018 Feb;181(2):185-191. doi: 10.1007/s12011-017-1042-y. Epub 2017 May 13. PMID: 28500578.
VOSSEL KA, XU JC, FOMENKO V, MIYAMOTO T, SUBERBIELLE E, KNOX JA, HO K, KIM DH, YU GQ, MUCKE L. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol. 2015 May 11;209(3):419-33. doi: 10.1083/jcb.201407065. PMID: 25963821; PMCID: PMC4427789.
WALSH KB, MCKINNEY AE EHOLMES AE (2021) Menor Canabinóides: Biossíntese Molecular Farmacologia e Potencial Usos Terapêuticos. Frente. Farmacol.12:777804.DOI:10.3389/fphar.2021.777804 Fronteira sem Farmacologia | Volume 12, 2021DOI: 10.3389/fphar.2021.777804
WONG TH, SEELAAR H, MELHEM S, ROZEMULLER AJM, VAN SWIETEN JC. Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations. Neurobiol Aging. 2020 Feb; 86:201. e9-201.e14. doi: 10.1016/j.neurobiolaging.2019.01.015. Epub 2019 Jan 29. PMID: 30797548.
XIE L, ZHANG N, ZHANG Q, LI C, SANDHU AF, III GW, LIN S, LV P, LIU Y, WU Q, YU S. Inflammatory factors and amyloid β-induced microglial polarization promote inflammatory crosstalk with astrocytes. Aging (Albany NY). 2020 Nov 16;12(22):22538-22549. doi: 10.18632/aging.103663. Epub 2020 Nov 16. PMID: 33196457; PMCID: PMC7746366.
YAMAMOTO A, YUE Z. Autophagy and its normal and pathogenic states in the brain." (“PKA compartmentalization links cAMP signaling and autophagy”) Annu Rev Neurosci. 2014; 37:55-78. doi: 10.1146/annurev-neuro-071013-014149. Epub 2014 Apr 21. PMID: 24821313.
YU JT, TAN L, HARDY J. Apolipoprotein E in Alzheimer's disease: an update. Annu Rev Neurosci. 2014; 37:79-100. doi: 10.1146/annurev-neuro-071013-014300. Epub 2014 Apr 21. PMID: 24821312.
ZENARO E, PIACENTINO G, CONSTANTIN G. The blood-brain barrier in Alzheimer's disease. Neurobiol Dis. 2017 Nov; 107:41-56. doi: 10.1016/j.nbd.2016.07.007. Epub 2016 Jul 15. PMID: 27425887; PMCID: PMC5600438.
