The effect of cannabidiol in the treatment of behavioral symptoms in children and adolescents with autism: an integrative review

O efeito do canabidiol no tratamento de sintomas comportamentais em crianças e adolescentes com autismo: uma revisão integrativa

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Resumo

Objective: to conduct an integrative review which seeks to analyze the effects of cannabidiol in children and adolescents with Autism Spectrum Disorder (ASD). Method: an integrative review was conducted following several methodological steps, including identifying the topic and formulating the research question using the PICO strategy. The guiding question was: "What is the effect of Cannabidiol (CBD) in the treatment of autism spectrum disorder (ASD) in children and adolescents?" Inclusion criteria were defined for selecting relevant articles, followed by the search and selection of articles in scientific databases Portal Capes and PubMed, with no use of search filters. The studies were evaluated and analyzed; the results were then interpreted. Finally, the integrative review consolidated knowledge about the possible effects of CBD as an intervention for ASD. Conclusion: the integrative review highlights the possible effects of cannabidiol (CBD) in the treatment of autism, showing significant improvement of symptoms with minimal side effects. Although still not widely disseminated, CBD appears to be a functional therapy for ASD.

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Referências

ALPERT, J. S. Autism: A Spectrum Disorder. American Journal of MedicineElsevier Inc., , 1 jun. 2021.

ARAN, A. et al. Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study. Journal of Autism and Developmental Disorders, v. 49, n. 3, p. 1284–1288, 15 mar. 2019a.

ARAN, A. et al. Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems—A Retrospective Feasibility Study. Journal of Autism and Developmental Disorders, v. 49, n. 3, p. 1284–1288, 15 mar. 2019b.

ARBERAS, C.; RUGGIERI, V. ARTÍCULO ESPECIAL AUTISMO. ASPECTOS GENÉTICOS Y BIOLÓGICOS. MEDICINA (Buenos Aires), v. 79, p. 16–21, 2019.

BAIRD, G.; CASS, H.; SLONIMS, V. Diagnosis of autism. British Medical JournalBMJ Publishing Group, , 30 ago. 2003.

BARCHEL, D. et al. Oral cannabidiol use in children with autism spectrum disorder to treat related symptoms and Co-morbidities. Frontiers in Pharmacology, v. 9, n. JAN, 2019.

BAR-LEV SCHLEIDER, L. et al. Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy. Scientific Reports, v. 9, n. 1, 1 dez. 2019a.

BAR-LEV SCHLEIDER, L. et al. Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy. Scientific Reports, v. 9, n. 1, 1 dez. 2019b.

BAR-LEV SCHLEIDER, L. et al. Real life Experience of Medical Cannabis Treatment in Autism: Analysis of Safety and Efficacy. Scientific Reports, v. 9, n. 1, 1 dez. 2019c.

DA SILVA JUNIOR, E. A. et al. Cannabis and cannabinoid use in autism spectrum disorder: a systematic review. Trends in Psychiatry and Psychotherapy, v. 44, 2022.

FLEURY-TEIXEIRA, P. et al. Effects of cbd-enriched cannabis sativa extract on autism spectrum disorder symptoms: An observational study of 18 participants undergoing compassionate use. Frontiers in Neurology, v. 10, n. OCT, 2019.

KODAK, T.; BERGMANN, S. Autism Spectrum Disorder: Characteristics, Associated Behaviors, and Early Intervention. Pediatric Clinics of North AmericaW.B. Saunders, , 1 jun. 2020.

LAI, M. C.; LOMBARDO, M. V.; BARON-COHEN, S. Autism. The Lancet. Anais...Elsevier B.V., 2014.

PONTON, J. A. et al. A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: A case report. Journal of Medical Case Reports, v. 14, n. 1, 22 set. 2020a.

PONTON, J. A. et al. A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: A case report. Journal of Medical Case Reports, v. 14, n. 1, 22 set. 2020b.

RAZ, N. et al. Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report. Frontiers in Pharmacology, v. 13, 28 out. 2022.

SILVA JUNIOR, E. A. DA et al. Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial. Trends in Psychiatry and Psychotherapy, 2022.

WANG, L. et al. Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy. International Journal of Molecular SciencesMDPI, , 1 fev. 2023.

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Publicado

2024-05-13

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