Effect of noise-induced stress on the hematological parameters of Wistar
O efeito do estresse sonoro nos parâmetros hematológicos de ratos Wistar
Palavras-chave:
Wistar rats, Noise stress, Hematological parametersResumo
The conflicts related to urban environmental issues interfere with perspectives on quality of life and stress levels. This study aimed to evaluate the influence of noise-induced stress on hematological parameters. Thirty young adult male Wistar lineage rats, weighing approximately 200g, were used and divided into 3 groups: group 1 (control) did not receive the stress factor, group 2 was exposed to standardized repetitive sound stimulus, with 15 minutes of silence and 15 minutes of noise, and a period of 8 hours of silence from 10:00 PM to 6:00 AM. Group 3 was exposed to non-repetitive sound stimulus. After seven weeks, the animals were euthanized, and blood was collected from the portal vein for hematological analysis upon confirmation of death. The animals group 2 had a lower percentage of weight gain compared to the control group, and the hematological analysis showed alterations in lymphocyte count, hemoglobin, erythrocytes, plasma proteins, and MCH. This study suggested that noise exposure may affect the immunological parameters of Wistar rats. The observed hematological alterations indicate the triggering of adaptive physiological mechanisms under the stress conditions to which the animals were subjected.
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Referências
ABOUEE-MEHRIZI, Amirreza et al. Inflammatory and immunological changes caused by noise exposure: A systematic review. Journal of Environmental Science and Health, Part C, v. 38, n. 1, p. 61-90, 2022.
CAMPELLO, Felipe Arrelaro. Poluição: Causas, consequências e soluções. Editora Senac São Paulo, 2023
CASTELHANO-CARLOS, Magda João; BAUMANS, V. The impact of light, noise, cage cleaning and in-house transport on welfare and stress of laboratory rats. Laboratory animals, v. 43, n. 4, p. 311-327, 2009.
CLARK C, Crumpler C, Notley AH. Evidence for environmental noise effects on health for the united kingdom policy context: a systematic review of the effects of environmental noise on mental health, wellbeing, quality of life, cancer, dementia, birth, reproductive outcomes, and cognition. Int J Environ Res Saúde Pública17:393. 2020;
De ALMEIDA, Sâmia Maria Barros; VON SÖHSTEN TRIGUEIRO, Janaína; DOS SANTOS CAVALCANTI, Marília Gabriela. Poluição sonora e o mapeamento do ruído urbano: revisão da literatura. Brazilian Journal of Development, v. 6, n. 10, p. 80776-80787, 2020.
ENCARNAÇÃO, R.de O. Estresse e produção Campo Grande, EMBRAPA-CNPGC, 1986.
ERASLAN E, Akyazi I, Ergul-Ekiz E, et al. Noise stress changes mRNA expressions of € corticotropin-releasing hormone, its receptors in amygdala, and anxiety-related behaviors. Noise Health.;17(76):141, 2015.
HAHAD O, Kuntic M, Al-Kindi S, Kuntic I, Gilan D, Petrowski K, Daiber A, Münzel T. Noise and mental health: evidence, mechanisms, and consequences. J Expo Sci Environ Epidemiol. 2024
HEKMAT A, Fahimi Z, Haeri Rohani S A. The effects of noise pollution on blood serum protein of Wistar male rats. NBR; 7 (1) :19-29;2020
ISAAC , Ao et al. Ameliorative effects of kaempferol and zinc gluconate on erythrocyte osmotic fragility and haematological parameters in wistar rats exposed to noise stress. Insights in Biomedicine, v. 2, n. 03, 2017.
LU, S.; WEI, F.; LI, G. The evolution of the concept of stress and the framework of the stress system. Cell Stress, v. 5, n. 6, p. 76–85, 2021.
MCEWEN, B. S.; AKIL, H. Revisiting the stress concept: Implications for affective disorders. Journal of Neuroscience, v. 40, n. 1, p. 12–21, 2020.
MÜNZEL T, Gori T, Babisch W, Basner M. Efeitos cardiovasculares da exposição ao ruído ambiente. Eur Coração J. 35:829–36; 2014.
NWUKE, Chinedu P. et al. Comparative studies on the effects of high sound levels on the haematological parameters and antioxidant levels of Wistar albino rats. Open Access Library Journal, v. 8, n. 03, p. 1, 2021.
PAULINUS, Nwuke Chinedu et al. Comparative Studies on the Effects of High Sound Levels on the Haematological Parameters and Antioxidant Levels of Wistar Albino Rats. Int Clinc Med Case Rep Jour. ; 3 (1): 1, v. 11; 2024
RUSSELL, G.; LIGHTMAN, S. The human stress response. Nature Reviews Endocrinology, v. 15,2019
RUSSO C, Russo A, Gulino R, Pellitteri R, Stanzani S. Effects of different musical frequencies on NPY and Ghrelin secretion in the rat hypothalamus. Brain Res Bull. 2017.
SCHULER AL, Pellegrino G. fMRI Acoustic Noise Enhances Parasympathetic Activity in Humans. Brain Sci. Oct 27;11(11):14162021.
SHE X, Gao X, Wang K, Yang H, Ma K, Cui B, Xi Z. Effects of noise and low-concentration carbon monoxide exposure on rat immunity. J Occup Health Jan;63(1):e12235. 2021.
